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Table 1 Baseline characteristics of training cohort and external validation cohort

From: Dynamic nomograms combining N classification with ratio-based nodal classifications to predict long-term survival for patients with lung adenocarcinoma after surgery: a SEER population-based study

Characteristic

Total

(n = 25,005)

Training cohort

(n = 13,551)

External validation cohort

(n = 11,454)

P value

N

%

N

%

N

%

Age at diagnosis (year)

      

< 0.001

  < 50

1288

5.2

806

5.9

482

4.2

 

 50–59

4898

19.6

2967

21.9

1931

16.9

 

 60–69

8830

35.3

4829

35.6

4001

34.9

 

 70–79

7683

30.7

3894

28.7

3789

33.1

 

  ≥ 80

2306

9.2

1055

7.8

1251

10.9

 

Sex

      

0.021

 Male

10,680

42.7

5878

43.4

4802

41.9

 

 Female

14,325

57.3

7673

56.6

6652

58.1

 

Race

      

< 0.001

 White

20,416

81.6

11,639

85.9

8777

76.6

 

 Black

2287

9.1

1638

12.1

649

5.7

 

 Other

2302

9.2

274

2.0

2028

17.7

 

Marital status at diagnosis

      

< 0.001

 Single

2942

11.8

1479

10.9

1463

12.8

 

 Married

14,917

59.7

8095

59.7

6822

59.6

 

 Other

7146

28.6

3977

29.3

3169

27.7

 

Laterality

      

0.026

 Right

15,015

60.0

8223

60.7

6792

59.3

 

 Left

9990

40.0

5328

39.3

4662

40.7

 

Site

      

0.006

 Main bronchus

40

0.2

21

0.2

19

0.2

 

 Upper lobe

15,359

61.4

8454

62.4

6905

60.3

 

 Middle lobe

1317

5.3

674

5.0

643

5.6

 

 Lower lobe

7983

31.9

4231

31.2

3752

32.8

 

 Over lapping lesion of lung

306

1.2

171

1.3

135

1.2

 

Differentiation

      

< 0.001

 I (Well differentiated)

4568

18.3

2298

17.0

2270

19.8

 

 II (Medium differentiated)

12,401

49.6

6655

49.1

5746

50.2

 

 III (Poorly differentiated)

7851

31.4

4506

33.3

3345

29.2

 

 IV (Undifferentiated)

185

0.7

92

0.7

93

0.8

 

T classification

      

0.028

 T1

11,856

47.4

6529

48.2

5327

46.5

 

 T2

8832

35.3

4701

34.7

4131

36.1

 

 T3

2976

11.9

1580

11.7

1396

12.2

 

 T4

1341

5.4

741

5.5

600

5.2

 

N classification

      

0.502

 N0

18,541

74.1

10,080

74.4

8461

73.9

 

 N1

3366

13.5

1774

13.1

1592

13.9

 

 N2

3098

12.4

1697

12.5

1401

12.2

 

Type of surgery

      

< 0.001

 Sublobectomy

2831

11.3

1707

12.6

1124

9.8

 

 Lobectomy

21,499

86.0

11,441

84.4

10,058

87.8

 

 Pneumonectomy

675

2.7

403

3.0

272

2.4

 

Radiotherapy

      

< 0.001

 No

22,786

91.1

12,262

90.5

10,524

91.9

 

 Yes

2219

8.9

1289

9.5

930

8.1

 

Chemotherapy

      

< 0.001

 No

18,282

73.1

9737

71.9

8545

74.6

 

 Yes

6723

26.9

3814

28.1

2909

25.4

 

NDLN

      

0.277

 NDLN1 (1–10)

15,958

63.8

8717

64.3

7241

63.2

 

 NDLN2 (11–19)

6399

25.6

3345

24.7

3054

26.7

 

 NDLN3 (≥20)

2648

10.6

1489

11.0

1159

10.1

 

NPLN

      

0.301

 NPLN0 (0)

18,726

74.9

10,186

75.2

8540

74.6

 

 NPLN1 (1–6)

5656

22.6

3022

22.3

2634

23.0

 

 NPLN2 (≥7)

623

2.5

343

2.5

280

2.4

 

LODDS

      

0.371

 LODDS1 (<−0.94)

15,712

62.8

8427

62.2

7285

63.6

 

 LODDS2 (≥ − 0.94, <−0.41)

6211

24.8

3451

25.5

2760

24.1

 

 LODDS3 (≥ − 0.41)

3082

12.3

1673

12.3

1409

12.3

 

LNR

      

0.045

 LNR0 (0)

18,726

74.9

10,186

75.2

8540

74.6

 

 LNR1 (> 0, < 0.55)

5120

20.5

2716

20.0

2404

21.0

 

 LNR2 (≥0.55, ≤1)

1159

4.6

649

4.8

510

4.5

 
  1. NDLN number of dissected lymph nodes; NPLN number of positive lymph nodes; LODDS log odds of positive lymph nodes; LNR lymph node ratio