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Table 3 Predictive value of EBV DNA for NPC development by different follow-up duration

From: Plasma Epstein-Barr virus DNA and risk of nasopharyngeal carcinoma in a prospective seropositive population

Variables > 2 years   > 3 years   > 4 years  
  Adjusted HR(95%CIs) P-value Adjusted HR(95%CIs) P-value Adjusted HR(95%CIs) P-value
≤3(undetectable) Reference   Reference   Reference  
> 3 (detectable) 10.878 (4.215–28.072) < 0.0001a 5.139 (1.136–23.252) 0.0336a 4.054 (0.500–32.845) 0.1898a
> 3–999 9.637 (3.491–26.607) < 0.0001b 2.785 (0.359–21.619) 0.3273b 4.472 (0.552–36.257) 0.3739b
≥1000 30.111 (3.662–247.587)   33.560 (3.996–281.872)   
  1. aHRs are adjusted by sex, age, smoking status, NPC family history, salted food,education level; b P trend for the comparision among EBV DNA undetectable group, DNA levels at > 3–999 copies/ml and DNA levels ≥1000 copies/ml