Table 2 Summary of decision-tree inputs
| Â | Input | Reference |
|---|---|---|
ALK determination strategies | ||
 IHC | 37.2% | [18] |
 FISH | 11.6% | [18] |
 Reflex | 46.5% | [18] |
 NGS | 4.7% | [18] |
Positivity rate in selected biomarkers | ||
 ALK+ | 3.4% | [18] |
 EGFR+ | 13.6% | [18] |
 ROS1+ | 2% | [18] |
 PD-L1 ≥ 50% | 33% | [18] |
 Percentage of invalid results | ||
 With IHC or FISH | 2.6% | [18] |
 With NGS | 3.4% | [19] |
Rebiopsy | ||
 Probability of rebiopsy if invalid | 77.1% | [20] |
Specificity and sensitivity | ||
 IHC | 97.9% / 96.8% | [21] |
 FISH | 99.8% / 90.9% | [22] |
 NGS | 100% | Assumptiona |