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Table 2 IC50 values of compounds 9, 10 and 11 and lawsone against C6, B16-F10 and A549

From: Anti-proliferative and pro-apoptotic activity of glycosidic derivatives of lawsone in melanoma cancer cell

Compounds

Cells

C6

B16F10

A549

CI50 (μM)

CI50 (μM)

CI50 (μM)

9

14.7 (10.3–21.4)

5.3 (4.8–5.8)

8.5 (7.6–9.5)

10

24.0 (16.5–80.1)

2.2 (1.0–4.0)

10.6 (6.9–18.1)

11

ND

15.7 (10.6–29.5)

21.2 (15.6–38.5)

Lawsone

26.8 (17.1–40.0)

ND

> 50

  1. Values expressed as mean and 95% confidence interval of at least three independent experiments after treatment with synthetic derivatives of lawsone and lawsone for 72 h. ND - not determined
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BMC Cancer

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