Table 1 PRLR Expression and ABBV-176 Cytotoxicity in Human Tumor Cell Lines
| Â | PRLR Expressiona | ABBV-176 IC50 (nM)b | h16f-MMAE IC50 (nM) b |
|---|---|---|---|
Breast cancer | |||
 T47D | 26,000 | 0.0055 (0.006) | 0.22 |
 CAMA1 | 10,000 | 0.01 | 5.2 |
 BT-474 | 10,000 | 0.24 (0.04) | 0.56 |
 MCF7 | 8000 | 0.32 (0.3) | > 22 |
 MDA-MB-361 | 5–10,000 | 0.77 (0.2) | 0.96 |
 SKBR3 | 5–10,000 | 0.26 | 3.67 |
 UACC812 | ~ 3500 | >  22 | > 22 |
 MDA-MB-231 | Below detection | >  22 | > 22 |
Prostate | |||
 22RV1 | 8000 | 0.01 | > 22 |
Endometrial | |||
 AN3CA | 8300 | 0.6 | 22 |
Ovarian | |||
 SMOV2 | ~ 2300 | 0.16 | > 22 |
Colorectal | |||
 SW403 | 11,000 | 0.11 | 17 |
Liver | |||
 HepG2 | n.d. | 8.6 | > 22 |
 HuH-7 | ~ 14,000 | 5.2 | > 22 |