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Fig. 8 | BMC Cancer

Fig. 8

From: ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes

Fig. 8

A model of A1542/A1543-mediated suppression of leukemia via cholesterol biosynthesis and role of latter in other types of cancer. a Activation of ERK/MAPK by ERK1/2 agonist A1542/A1543 induces genes including SREBPs, EGR1 and AP1 (JUN-FOS) involved in cholesterol biosynthesis, as well as other death promoting signals, together responsible for leukemia inhibition in culture and in vivo. b TCGA analysis of renal cancer survival as a function of elevated cholesterol biosynthesis genes

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BMC Cancer

ISSN: 1471-2407

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