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Fig. 4 | BMC Cancer

Fig. 4

From: ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes

Fig. 4

Selected regulation of cholesterol genes by SREBPs. a,b Expression of SREBP1 (a) and SREBP2 (b) in HEL cells treated with A1542 (1 μM). c-e Expression of SREBP1 (c), SREBP1 (d) and SREBP2 (e) in HEL cells transduced by shRNA for SREBP1 (shSREBP1) or scrambled control. f Growth rate properties of shSREBP1 and scrambled-HEL cells in culture. g-k Q-RT-PCR analysis of shSREBP1 and control cells for the indicated cholesterol genes treated with A1542 (1 μM) or DMSO for 24 h

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BMC Cancer

ISSN: 1471-2407

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