Fig. 2
Induction of cholesterol biosynthesis and cellular proliferation are inhibited by Lovastatin. a,b Western blot of HEL cells treated with A1542 (a) or A1543 (b) for 24 h with or without LOV (10 μM). Relative intensity (Rd) of bands was calculated using densitometer. c IC50 determination of the indicated drugs for cell lines HEL and CB3 for three days in culture. d Growth rate of HEL cells treated with the indicated compounds. P < 0.0001 denoted by ****. e Level of total cholesterol in HEL cells treated with Cholesterol (15uM) and DMSO for 24 h. P < 0.05 denoted by *