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Table 7 Univariate and multivariate analysis of different prognostic factors for overall survival

From: Metastatic colo-rectal cancer: real life experience from an Indian tertiary care center

Variable

n

Univariate Analysis

Multivariate analysis

HR

p

95% CI

HR

p

95% CI

Sex

 Female

158

1.06

0.716

0.74–1.52

   

 Male

219

      

Elderly

  > 65 yrs

33

0.7

0.298

0.38–1.33

   

  ≤ 65 yrs

344

      

Young

  ≤ 40 yrs

144

1.31

0.91

0.83–1.89

   

  > 40 yrs

233

      

ECOG

  ≥ 2

89

1.79

0.005

1.18–2.70

2.0

0.003

1.3–3.3

 0–1

223

      

Upfront

 Metastasis

259

1.23

0.297

0.83–1.81

   

 Relapsed

118

      

Hb(g/dl)

  < 10.8

165

1.45

0.076

0.96–2.04

   

  ≥ 10.8

156

      

CEA

 High

228

1.94

0.019

1.16–3.38

2.47

0.004

1.33–4.6

 Normal

65

      

Albumin(g/dl)

  < 3.5

54

2.48

0.001

1.56–3.95

1.71

0.045

1.0–2.9

  ≥ 3.5

263

      

Sidedness

 Left

285

0.72

0.124

0.48–1.09

   

 Right

75

      

Grade

 Poorly

19

2.11

0.077

0.92–4.85

   

 Moderately / Well

304

      

Morphology

 Signet / Mucinous

108

1.43

0.072

0.96–2.11

   

 Adenoca NOS

216

      

SAP

 High

11

1.57

0.442

0.49–4.98

   

 Normal

296

      

No of organs involved

  ≥ 2

89

1.43

0.085

0.95–2.15

   

 1

287

      

Liver metastasis

 Yes

161

0.98

0.90

0.68–1.39

   

 No

216

      

Peritoneum metastasis

 Yes

118

1.3

0.155

0.90–1.92

   

 No

259

      

Number of liver metastasis

  > 3

89

1.15

0.712

0.62–1.99

   

  ≤ 3

51

      

1st Line

 Irinotecan

90

1.1

0.54

0.76–1.6

   

 Oxaliplatin

247

      

Number of lines of CT

  > 1

124

0.48

0.001

0.32–0.7

0.47

0.001

0.3–0.74

 1

253

      
  1. CT Chemotherapy, Hb hemoglobin, ECOG Eastern Cooperative Oncology group, CEA carcinoembryonic antigen, High CEA > 5 ng/ml, SAP Serum Alkaline Phosphate, CI Confidence interval, HR Hazard Ratio
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