Table 3 Summary
From: Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage
|  | Low-risk HPV | Low-risk HPV + EBV | High-risk HPV + EBV |
|---|---|---|---|
Proliferative activity | – | ++ | +++ |
DNA damage | + | +++ | +++ |
Apoptotic suppression | – | + | ++ |
NF-κB activation | – | ++ | +++ |
Inactivation of p53 | – | ++ | +++ |
Invasive ability | – | ± | + |
Anchorage-independent growth | – | – | + |
Tumor formation in nude mice | – | – | + |
Activation of adhesion signaling including paxillin, MMP2 | – | – | + |