Univariate (N = 18,264) | Multivariate (N = 18,264) | ||||||
---|---|---|---|---|---|---|---|
Variables | late or no access / early access | OR | IC 95% | p-value | OR | IC 95% | p-value |
Individual and clinical variables | |||||||
Sex | 0.0093 | ||||||
Male | 6421/2797 | 1 | |||||
Female | 6460/2586 | 1.08 | [1.02;1.16] | ||||
Age | < 0.0001 | < 0.0001 | |||||
[18–25] | 335/299 | 1 | 1 | ||||
[25–50] | 2988/1507 | 1.77 | [1.49;2.09] | 1.33 | [1.10;1.60] | ||
[50–75] | 6286/2516 | 2.23 | [1.89;2.62] | 1.65 | [1.38;1.99] | ||
> =75 | 3272/1061 | 2.75 | [2.32;3.26] | 1.85 | [1.52;2.25] | ||
Year of diagnosis | < 0.0001 | < 0.0001 | |||||
2011 | 2972/944 | 1 | 1 | ||||
2012 | 3034/1173 | 0.82 | [0.74;0.90] | 0.78 | [0.70;0.87] | ||
2013 | 3390/1576 | 0.68 | [0.62;0.75] | 0.79 | [0.71;0.88] | ||
2014 | 3485/1690 | 0.65 | [0.59;0.71] | 0.68 | [0.61;0.75] | ||
Type of tumour | < 0.0001 | < 0.0001 | |||||
Soft tissue | 8187/4073 | 1 | 1 | ||||
Bone | 415/637 | 0.32 | [0.28;0.36] | 0.35 | [0.29;0.42] | ||
Viscera – GIST | 2190/247 | 4.41 | [3.84;5.05] | 1.99 | [1.32;3.00] | ||
Viscera - No GIST | 2089/426 | 2.44 | [2.18;2.72] | 3.56 | [3.16;4.01] | ||
Depth of tumour | < 0.0001 | < 0.0001 | |||||
Superficial and deep | 667/377 | 1 | 1 | ||||
Superficial | 3312/590 | 3.17 | [2.721;3.7] | 2.15 | [1.83;2.54] | ||
Deep | 7903/3835 | 1.16 | [1.02;1.32] | 0.82 | [0.71;0.95] | ||
Missing | 999/581 | 0.97 | [0.82;1.14] | 1.35 | [1.09;1.66] | ||
Size of tumour | < 0.0001 | < 0.0001 | |||||
> =200 | 707/641 | 1 | 1 | ||||
[50–200] | 5242/3070 | 1.54 | [1.37;1.73] | 1.40 | [1.24;1.59] | ||
[0–50] | 4486/1044 | 3.89 | [3.43;4.42] | 2.58 | [2.23;2.98] | ||
Missing | 2446/628 | 3.53 | [3.07;4.05] | 2.80 | [2.39;3.28] | ||
Histotype category | < 0.0001 | < 0.0001 | |||||
Sarcoma | 6809/4027 | 1 | 1 | ||||
GIST | 2323/281 | 4.88 | [4.29;5.56] | 1.43 | [0.96;2.14] | ||
Tumour of intermediate malignancy | 3749/1075 | 2.06 | [1.90;2.23] | 2.07 | [1.87;2.30] | ||
Grade | < 0.0001 | < 0.0001 | |||||
1 | 1204/746 | 1 | 1 | ||||
2 | 4373/1723 | 1.57 | [1.41;1.75] | 1.01 | [0.90;1.10] | ||
3 | 1771/1382 | 0.79 | [0.70;0.89] | 0.92 | [0.81;1.05] | ||
Not applicable | 1304/808 | 1 | [0.88;1.13] | 0.94 | [0.81;1.10] | ||
Missing | 4229/724 | 3.61 | [3.20;4.08] | 2.59 | [2.22;3.02] | ||
Geographical variables | |||||||
Region | < 0.0001 | < 0.0001 | |||||
Auvergne-Rhône-Alpes | 1556/776 | 1 | 1 | ||||
Grand-Est | 1051/519 | 1.01 | [0.88;1.15] | 0.91 | [0.78;1.06] | ||
Nouvelle-Aquitaine | 1457/634 | 1.14 | [1.00;1.30] | 0.93 | [0.81;1.08] | ||
Bourgogne-Franche-Comté | 594/277 | 1.06 | [0.90;1.26] | 0.94 | [0.78;1.13] | ||
Centre-Val de Loire | 484/219 | 1.10 | [0.91;1.32] | 0.98 | [0.80;1.20] | ||
Pays-de-la-Loire | 718/318 | 1.12 | [0.96;1.31] | 0.98 | [0.82;1.17] | ||
Occitanie | 1242/561 | 1.10 | [0.96;1.26] | 1.05 | [0.91;1.21] | ||
Hauts-de-France | 1024/457 | 1.11 | [0.97;1.28] | 1.08 | [0.93;1.27] | ||
Ile-de-France | 1991/781 | 1.27 | [1.12;1.43] | 1.12 | [0.97;1.29] | ||
Bretagne | 761/237 | 1.60 | [1.35;1.89] | 1.31 | [1.09;1.59] | ||
Normandie | 420/168 | 1.24 | [1.02;1.52] | 1.34 | [1.08;1.67] | ||
Provence-Alpes-Côte-d’Azur | 1485/412 | 1.79 | [1.56;2.06] | 1.52 | [1.31;1.77] | ||
Corse | 98/24 | 2.03 | [1.29;3.20] | 1.57 | [0.95;2.58] | ||
GeoClasH classification of municipalities | 0.1696 | ||||||
Wealthy Metropolitan Areas | 2763/1132 | 1 | |||||
Precarious Population Districts | 6758/2827 | 0.97 | [0.90;1.06] | ||||
Residential Outskirts | 1586/721 | 0.90 | [0.80;1.00] | ||||
Agricultural and Industrial Plains | 1122/428 | 1.07 | [0.94;1.22] | ||||
Rural Margins | 652/275 | 0.97 | [0.83;1.13] | ||||
Travel time to the closest sarcoma reference centre (in minutes, quintiles) | 0.004 | 0.0013 | |||||
< = 29 | 2576/1168 | 1 | 1 | ||||
[ 29; 56] | 2555/1069 | 1.08 | [0.98;1.19] | 1.12 | [1.00;1.25] | ||
[ 56; 79] | 2561/1122 | 1.03 | [0.93;1.14] | 1.07 | [0.96;1.20] | ||
[ 79; 102] | 2507/1009 | 1.12 | [1.01;1.24] | 1.21 | [1.08;1.36] | ||
> 102 | 2682/1015 | 1.19 | [1.08;1.32] | 1.24 | [1.10;1.40] | ||
European Deprivation Index (quintiles) | 0.04 | ||||||
< = − 1.3 (least deprived) | 2551/1115 | 1 | |||||
[-1.3; 1.8] | 2527/1086 | 1.01 | [0.92;1.12] | ||||
[1.8; 5.6] | 2648/1038 | 1.11 | [1.00;1.23] | ||||
[5.6; 9.2] | 2584/1135 | 0.99 | [0.90;1.09] | ||||
> 9.2 (most deprived) | 2571/1009 | 1.11 | [1.00;1.23] | ||||
Population density (number of inhabitants/km2, quintiles) | 0.8876 | ||||||
< = 94.0926 | 2579/1089 | 1 | |||||
[ 94.0926; 306.127] | 2541/1084 | 0.99 | [0.89;1.09] | ||||
[ 306.127; 1034.61] | 2566/1080 | 1.00 | [0.90;1.10] | ||||
[ 1034.61; 3693.94] | 2597/1054 | 1.04 | [0.94;1.15] | ||||
> 3693.94 | 2598/1076 | 1.02 | [0.92;1.12] | ||||
APL index (spatial accessibility to general practitioners, quintiles) | 0.8087 | ||||||
< = 49.1 (lowest accessibility) | 2546/1076 | 1 | |||||
[ 49.1; 64] | 2575/1105 | 0.98 | [0.89;1.08] | ||||
[ 64; 78.4] | 2517/1033 | 1.03 | [0.93;1.14] | ||||
[ 78.4; 90.7] | 2666/1082 | 1.04 | [0.94;1.15] | ||||
> 90.7 (highest accessibility) | 2577/1087 | 1.00 | [0.90;1.10] |