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Fig. 3 | BMC Cancer

Fig. 3

From: Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

Fig. 3

A Using weighted averages derived from the screen data we predicted likely sensitivity to gemcitabine based on expression of resistance-associated genes (PKG). There is a significant difference in survival between patients with predicted high versus low gemcitabine sensitivity (p = 0.01, Chi-squared test). B Predicted Gemcitabine Sensitivity was calculated using a weighted average of gene expression for resistance-associated genes based on expression profiles for 18 pancreatic cancer cell lines. These data were plotted compared to experimentally measured IC50 groups (Low: IC50 < 20uM, Moderate: 100uM < IC50 < 300; High: IC50 > 300uM. The Wilcoxon P-value between the most resistant group of cell lines and the most sensitive is 0.097. C Scatterplot showing observed irinotecan IC50 values compared to predicted sensitivity for 18 PDAC cells assayed by the Cancer Cell Line Encyclopedia. (Rho = 0.44, p = 0.06)

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BMC Cancer

ISSN: 1471-2407

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