Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

Fig. 1

CRISPR screen reveals drug resistance genes. A Schematic describing our screening protocol. B A scatterplot shows the mean L2FC sum for all four drugs assayed in each of two cell lines compared to the log10 p-value for the association of the same gene’s expression with with patient survival. ABCG2 stands out as the most highest L2FC over all four drugs. C Boxplots indicate the sgRNA fold change in counts per million comparing treated cells to control cells for each replicate and each cell line for the top ABCG2 sgRNA. Circles represent data from Panc-1 cells. Squares represent BXPC-3

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us