Fig. 1

X-Tile analysis of survival data from the Surveillance, Epidemiology, and End Results (SEER) registry. X-Tile analysis was performed using patient data from the SEER registry. The plot showed the χ2 log-rank values produced when dividing the cohort with two cut-points, producing low and high subsets. The X-axis represented all potential cut-off point from low to high that defined a low subset, while the Y-axis represented the high to low cut-off points that defined a high subset. The arrows indicated the direction in which the size of the low subset (X-axis) and the high subset (Y-axis) increased. A The red coloration of cut-points indicates an negative correlation with survival, whereas green coloration represents positive correlation. X-Tile plot of the patient age divided at the mean age, the optimal cut-point highlighted by the black circle in middle of the color bar. B Histogram of the entire cohort, optimal cut-off values of age at diagnosis were identified as 53 years based on cancer-specific survival (CSS). The X-axis is the age of patients, and the Y-axis is the number of patients at that age. C Kaplan-Meier survival curve developed based on these cutoff values