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Table 4 Analysis by medical history. Mutations are reported according to personal and familial history for cancer

From: Comprehensive analysis of DNA damage repair genes reveals pathogenic variants beyond BRCA and suggests the need for extensive genetic testing in pancreatic cancer

  Mutations
C4/C5 VUS no
Personal history
Yes 1 5 4
No/unknown 7 10 33
Familial history
Yes 4 5 14
No/unknown 4 10 23
  1. C4/C5 Likely pathogenic (C4) or pathogenic (C5) according to the IARC classification, VUS Variants of uncertain significance