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Fig. 3 | BMC Cancer

Fig. 3

From: Differential chromatin accessibility landscape of gain-of-function mutant p53 tumours

Fig. 3

Enhancer and histone marks overlap with the differential accessible peaks a, b The pie-chart shows the proportion of lost (left) and gained (right) peaks overlapped with the predicted enhancer regions (from GeneHancer) and H3K27ac mark from relevant cancer cell lines (harbouring gain-of-function mutations in p53) for breast and colon cancers. c Heatmap shows the chromatin accessibility score centred at the gained peaks (and immediate flanking regions) in breast cancer that overlapped histone marks (including those that overlapped both histone marks and enhancer predictions) from MDA-MB-468 cell line (top), only the enhancer predictions (middle) or none (bottom). The column represents the individual sample that belongs to either mutant or wild-type p53 group. d Similar heatmap for the lost peaks in breast cancer

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