Fig. 1

Differential chromatin accessible regions in mutant p53 tumours. a, b Volcano plot shows the differential chromatin accessible peaks in the mutant p53 with respect to the wild-type p53 tumours in breast infiltrating ductal carcinoma (left) and colon adenocarcinoma (right). Each dot represents a peak region and the colour represents the genomic annotation (for significant candidates). The x-axis represents log2 fold change of accessible score in mutant versus wild-type p53 tumours, and the y-axis shows the -log10 adjusted p-value. The vertical and horizontal dashed lines indicate the threshold of FDR (q-value) < 0.1 and |log2FoldChange(Accessibility)| of 1. The symbol X indicates the peaks that overlapped cancer driver genes [18]. The pie chart on the top represents the distribution of each genomic feature in significant lost and gained peaks, where n represents the total number of significant peaks. c, d The donut plot shows the distribution of closest peak distance for significant lost (left) and gained (right) peaks compared to the non-significant peaks. Each circle represents a distance bin and the stacks within that represent the peaks with specific genomic annotation (as shown in panels a and b). The pie chart inside represents the overall proportion of peaks that fall under each distance group (highlighted with the same colour code mentioned at the center of the donut plot). e, f Upset R plot showing distribution and overlap within different sets of annotations of the significant lost and gained peaks