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Table 3 Analysis of 7 selected genes by GO and KEGG pathway enrichment. FDR, false discovery rate. GO, gene ontology; BP, biological process, CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEMs, differentially expressed miRNAs

From: Identification of novel hub genes associated with gastric cancer using integrated bioinformatics analysis

Category

Term

Count

%

PValue

Genes

FDR

GOTERM_BP_DIRECT

GO:0048146 ~ positive regulation of fibroblast proliferation

3

0.263

1.51E-04

CCNB1, CCNA2, FN1

0.174735

GOTERM_BP_DIRECT

GO:0051301 ~ cell division

3

0.263

0.006147477

CCNB1, MAD2L1, CCNA2

6.892135

GOTERM_BP_DIRECT

GO:0051436 ~ negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

2

0.175

0.025106263

CCNB1, MAD2L1

25.50655

GOTERM_BP_DIRECT

GO:0051437 ~ positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition

2

0.175

0.026854324

CCNB1, MAD2L1

27.03882

GOTERM_BP_DIRECT

GO:0022617 ~ extracellular matrix disassembly

2

0.175

0.026854324

SPP1, FN1

27.03882

GOTERM_BP_DIRECT

GO:0031145 ~ anaphase-promoting complex-dependent catabolic process

2

0.175

0.027901906

CCNB1, MAD2L1

27.94322

GOTERM_BP_DIRECT

GO:0071456 ~ cellular response to hypoxia

2

0.175

0.033820471

CCNB1, CCNA2

32.86331

GOTERM_BP_DIRECT

GO:0000086 ~ G2/M transition of mitotic cell cycle

2

0.175

0.047971221

CCNB1, HMMR

43.40814

GOTERM_BP_DIRECT

GO:0042787 ~ protein ubiquitination involved in ubiquitin-dependent protein catabolic process

2

0.175

0.053446406

CCNB1, MAD2L1

47.06463

GOTERM_BP_DIRECT

GO:0030198 ~ extracellular matrix organization

2

0.175

0.068031098

SPP1, FN1

55.77698

GOTERM_BP_DIRECT

GO:0001525 ~ angiogenesis

2

0.175

0.077092848

CXCL8, FN1

60.50819

GOTERM_CC_DIRECT

GO:0000922 ~ spindle pole

2

0.175

0.035359174

CCNB1, MAD2L1

26.96429

GOTERM_CC_DIRECT

GO:0005615 ~ extracellular space

3

0.263

0.067058677

CXCL8, SPP1, FN1

45.44016

GOTERM_CC_DIRECT

GO:0005576 ~ extracellular region

3

0.263

0.092078284

CXCL8, SPP1, FN1

56.9647

GOTERM_MF_DIRECT

GO:0005515 ~ protein binding

7

0.613

0.019847501

CCNB1, MAD2L1, CXCL8, CCNA2, SPP1, FN1, HMMR

13.51086

KEGG_PATHWAY

hsa04512:ECM-receptor interaction

3

0.263

0.002294922

SPP1, FN1, HMMR

2.054976

KEGG_PATHWAY

hsa04914:Progesterone-mediated oocyte maturation

3

0.263

0.002294922

CCNB1, MAD2L1, CCNA2

2.054976

KEGG_PATHWAY

hsa04110:Cell cycle

3

0.263

0.004611117

CCNB1, MAD2L1, CCNA2

4.090835

KEGG_PATHWAY

hsa05146:Amoebiasis

2

0.175

0.088997082

CXCL8, FN1

56.93087

KEGG_PATHWAY

hsa04620:Toll-like receptor signaling pathway

2

0.175

0.088997082

CXCL8, SPP1

56.93087

KEGG_PATHWAY

hsa04114:Oocyte meiosis

2

0.175

0.093026279

CCNB1, MAD2L1

58.62208

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BMC Cancer

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