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Fig. 1 | BMC Cancer

Fig. 1

From: Head and neck squamous cell carcinoma cell lines have an immunomodulatory effect on macrophages independent of hypoxia and toll-like receptor 9

Fig. 1

Changes in the relative phenotypical features of non-activated macrophages post conditioned media treatment (a) Outline of the conditioned media (CM) -experiment. (b, c, d) Following incubation with CMNOX for two days, macrophage (MΦ) polarization was assessed with flow cytometry. Panels b, c, and d illustrate M1, M2a and M2c polarization markers, respectively. UT-SCC-8 and UT-SCC-74A are abbreviated here as SCC-8 and SCC-74A. Box plots represent a comparison of normalized MFI (nMFI) values against NA MΦ (dotted line), error bars 95% CI. Experiments were repeated a minimum of 5 times. *p ≤ 0.05 vs. NA MΦ was considered statistically significant (the exact p-values can be found in Additional file F7b)

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