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Fig. 6 | BMC Cancer

Fig. 6

From: Metformin alters therapeutic effects in the BALB/c tumor therapy model

Fig. 6

Combined treatment with chemotherapeutic agents plus metformin in the BALB-TTM. a The BALB/c 3 T3 cell transformation assay was performed as described earlier. An additional treatment was conducted on day 32 with Doxorubicin, Doxetaxel, Mitomycin C or 5-Fluorouracil alone or in combination with metformin for 72 h and cell were fixed on day 35. The number of type-III foci of 4 biological replicates (mean + SD) are shown for different concentrations of b Doxorubicin, c Docetaxel, d Mitomycin C and e 5-Fluorouracil in combination with 1 mM metformin. Statistical differences were calculated with a one-way ANOVA (post-hoc: Bonferroni) with * = (p < 0.05) and *** = (p < 0.001) vs. control

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