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Fig. 4 | BMC Cancer

Fig. 4

From: Genomic stratification based on microenvironment immune types and PD-L1 for tailoring therapeutic strategies in bladder cancer

Fig. 4

CNVs and DEGs associated with mRNA expression levels and correlated with the overall survival of bladder cancer patients. a Differential CNVs between the PD-L1-low-exhausted group and the other groups. Circle: Differential CNV-associated genes in samples according to their chromosomal location. Genes that were gained are labelled in black, and genes that were deleted are labelled in blue. b DEGs between the PD-L1-low-exhausted group and the other groups. c Venn diagram of the DEGs and CNVs associated with mRNA expression levels. d Correlation between different CNV patterns and mRNA expression levels. e Kaplan-Meier plots of key genes. f. Heatmap depicting immune modulation in the immune subgroups in the GEO validation database. Each row indicates a gene, and each column indicates a sample. g RASL11B expression was significantly upregulated in the PD-L1-low-exhausted group compared with the other groups in the GEO validation database

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