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Table 5 Odds ratios and 95% confidence intervals for the association of metabolic comorbidities across different breast cancer subtype with the risk of recurrent metastatic disease using binary logistic regression. Individual and concurrent metabolic variables were included in the multivariable analysis

From: Metabolic comorbidities and the association with risks of recurrent metastatic disease in breast cancer survivors

Variables

Luminal A (N = 497)

Luminal B (N = 123)

Her2-enriched (N = 174)

TNBC (N = 287)

OR

95%CI

P value

OR

95%CI

P value

OR

95%CI

P value

OR

95%CI

P value

DM or glucose intolerance

1.054

0.680–1.632

0.815

5.697

2.278–14.248

< 0.001

2.004

0.967–4.149

0.061

1.022

0.434–2.405

0.961

Dyslipidemia

0.837

0.543–1.291

0.422

1.548

0.644–3.723

0.329

1.068

0.483–2.360

0.871

1.204

0.635–2.282

0.569

Hypertension

0.782

0.522–1.172

0.234

1.791

0.759–4.229

0.183

1.111

0.561–2.202

0.763

0.972

0.563–1.679

0.919

BMI risk (> 27.7)

1.145

0.730–1.798

0.514

1.410

0.544–3.653

0.480

0.730

0.293–1.820

0.499

0.795

0.416–1.520

0.488

DM/glucose intolerance + Dyslipidemia

1.227

0.732–2.058

0.438

9.100

2.495–33.196

0.001

1.513

0.569–4.026

0.407

1.675

0.758–3.705

0.202

DM/glucose intolerance + Hypertension

1.069

0.670–1.704

0.781

5.467

2.124–14.072

< 0.001

2.304

1.071–4.959

0.033

1.187

0.618–2.281

0.607

Dyslipidemia + Hypertension

0.893

0.613–1.378

0.613

1.812

0.748–4.391

0.188

1.167

0.525–2.593

0.705

1.150

0.600–2.206

0.672

Dyslipidemia + BMI risk

1.002

0.568–1.766

0.995

0.916

0.237–3.543

0.899

1.245

0.308–5.034

0.759

0.855

0.350–2.089

0.730

Hypertension + BMI risk

1.001

0.598–1.677

0.997

1.258

0.410–3.860

0.688

1.027

0.348–3.032

0.962

1.000

0.474–2.109

1.000

DM/glucose intolerance + BMI risk

1.076

0.549–2.108

0.831

2.359

0.374–14.874

0.361

0.811

0.162–4.053

0.798

1.099

0.410–2.942

0.852

≥3 metabolic comorbidities

1.330

0.850–2.082

0.212

5.014

1.969–12.767

0.001

1.447

0.602–3.482

0.409

1.576

0.817–3.040

0.175

Any metabolic comorbidity

0.833

0.556–1.247

0.374

2.554

0.948–6.879

0.064

0.905

0.458–1.788

0.773

0.794

0.469–1.344

0.391