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Table 5 Odds ratios and 95% confidence intervals for the association of metabolic comorbidities across different breast cancer subtype with the risk of recurrent metastatic disease using binary logistic regression. Individual and concurrent metabolic variables were included in the multivariable analysis

From: Metabolic comorbidities and the association with risks of recurrent metastatic disease in breast cancer survivors

Variables Luminal A (N = 497) Luminal B (N = 123) Her2-enriched (N = 174) TNBC (N = 287)
OR 95%CI P value OR 95%CI P value OR 95%CI P value OR 95%CI P value
DM or glucose intolerance 1.054 0.680–1.632 0.815 5.697 2.278–14.248 < 0.001 2.004 0.967–4.149 0.061 1.022 0.434–2.405 0.961
Dyslipidemia 0.837 0.543–1.291 0.422 1.548 0.644–3.723 0.329 1.068 0.483–2.360 0.871 1.204 0.635–2.282 0.569
Hypertension 0.782 0.522–1.172 0.234 1.791 0.759–4.229 0.183 1.111 0.561–2.202 0.763 0.972 0.563–1.679 0.919
BMI risk (> 27.7) 1.145 0.730–1.798 0.514 1.410 0.544–3.653 0.480 0.730 0.293–1.820 0.499 0.795 0.416–1.520 0.488
DM/glucose intolerance + Dyslipidemia 1.227 0.732–2.058 0.438 9.100 2.495–33.196 0.001 1.513 0.569–4.026 0.407 1.675 0.758–3.705 0.202
DM/glucose intolerance + Hypertension 1.069 0.670–1.704 0.781 5.467 2.124–14.072 < 0.001 2.304 1.071–4.959 0.033 1.187 0.618–2.281 0.607
Dyslipidemia + Hypertension 0.893 0.613–1.378 0.613 1.812 0.748–4.391 0.188 1.167 0.525–2.593 0.705 1.150 0.600–2.206 0.672
Dyslipidemia + BMI risk 1.002 0.568–1.766 0.995 0.916 0.237–3.543 0.899 1.245 0.308–5.034 0.759 0.855 0.350–2.089 0.730
Hypertension + BMI risk 1.001 0.598–1.677 0.997 1.258 0.410–3.860 0.688 1.027 0.348–3.032 0.962 1.000 0.474–2.109 1.000
DM/glucose intolerance + BMI risk 1.076 0.549–2.108 0.831 2.359 0.374–14.874 0.361 0.811 0.162–4.053 0.798 1.099 0.410–2.942 0.852
≥3 metabolic comorbidities 1.330 0.850–2.082 0.212 5.014 1.969–12.767 0.001 1.447 0.602–3.482 0.409 1.576 0.817–3.040 0.175
Any metabolic comorbidity 0.833 0.556–1.247 0.374 2.554 0.948–6.879 0.064 0.905 0.458–1.788 0.773 0.794 0.469–1.344 0.391