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Table 1 Patients characteristics and univariate analysis

From: Development of a nomogram model to predict survival outcomes in patients with primary hepatic neuroendocrine tumors based on SEER database

Variables

Survival time

Survival number and rate

Univariate analysis

Number

Mean survival time [95% CI] (months)

1-year survival

3-years survival

5-years survival

Total number

140

 

Number

Rate [95%CI]

Number

Rate [95%CI]

Number

Rate [95%CI]

HR [95%CI]

P-value

Age (years):

         

0.002

 00–24:

1

16.00

–

–

–

–

–

–

Ref

 

 25–49:

28

50.75 (35.20–66.30)

22

78.57 (60.46–89.79)

15

53.57 (35.81–70.47)

9

32.14 (17.93–50.66)

1.04 (0.14–7.58)

0.97

 50–74:

68

30.33 (21.98–38.68)

36

52.94 (41.24–64.33)

22

32.35 (22.44–44.16)

15

22.06 (13.85–33.26)

0.38 (0.23–0.63)

0.00

  > 75:

43

18.05 (10.82–25.28)

20

46.51 (32.51–61.08)

5

11.63 (5.07–24.48)

2

4.65 (1.28–15.46)

0.64 (0.43–0.96)

0.03

Race:

         

0.20

 black:

24

25.96 (15.72–36.20)

15

62.50 (42.71–78.84)

6

25.00 (12.00–44.90)

3

12.50 (4.34–31.00)

Ref

 

 other:

9

16.78 (0.92–32.63)

4

44.44 (18.88–73.33)

1

11.11 (1.99–43.50)

1

–

1.25 (0.79–1.96)

0.34

 white:

107

33.05 (25.82–40.29)

60

56.07 (46.62–65.11)

35

32.71 (24.55–42.06)

22

20.56 (13.99–29.17)

1.73 (0.87–3.43)

0.12

Sex:

         

0.24

 Female:

85

33.29 (25.58–41.01)

49

57.65 (47.04–67.60)

27

31.76 (22.84–42.27)

18

21.18 (13.84–31.01)

Ref

 

 Male:

55

26.84 (17.73–35.94)

30

54.55 (41.52–66.97)

15

27.27 (17.28–40.23)

8

14.55 (7.56–26.16)

0.82 (0.58–1.15)

0.25

Marital status:

         

0.78

 Married:

75

32.57 (23.89–41.25)

45

60.00 (48.69–70.34)

21

28.00 (19.10–39.04)

14

18.67 (11.46–28.93)

Ref

 

 Unmarried:

26

31.54 (16.84–46.24)

13

50.00 (32.06–67.94)

10

38.46 (22.43–57.47)

6

23.08 (11.03–42.05)

0.87 (0.43–1.76)

0.70

 Separated:

30

25.96 (15.40–36.52)

14

46.67 (30.23–63.86)

9

30.00 (16.66–47.88)

5

16.67 (7.34–33.56)

0.86 (0.40–1.87)

0.71

 Unknown:

9

28.00 (15.45–40.55)

–

 

–

 

–

 

–

–

Insurance:

         

0.002

 Yes:

105

28.06 (22.56–33.56)

63

60.00 (50.44–68.86)

30

28.57 (20.81–37.85)

18

17.14 (11.13–25.48)

Ref

 

 No:

8

10.25 (0.00–22.04)

1

12.50 (2.24–47.09)

1

12.50 (2.24–47.09)

0

–

1.96 (1.18–3.27)

0.009

 unknown

27

48.54 (27.33–69.76)

      

–

–

Tumor grade:

         

0.00

 I:

56

47.57 (37.67–57.48)

50

89.29 (78.53–95.00)

28

50.00 (37.33–62.67)

16

28.57 (18.42–41.48)

Ref

 

 II:

25

41.84 (27.99–55.68)

18

72.00 (52.42–85.72)

11

44.60 (26.67–62.93)

8

32.00 (17.21–51.59)

0.16 (0.08–0.32)

0.00

 III:

47

9.57 (4.66–14.48)

11

23.40 (13.60–37.22)

2

4.26 (1.17–14.25)

1

2.13 (0.38–11.11)

0.20 (0.10–0.41)

0.29

 IV:

12

5.58 (0.00–12.36)

1

8.33 (1.49–35.39)

0

–

0

–

0.71 (0.37–1.34)

0.00

 Unknown:

0

         

Tumor size:

         

0.44

  < 3 cm:

22

35.14 (16.93–53.34)

13

59.09 (38.73–76.74)

7

31.82 (16.36–52.68)

5

22.73 (10.12–43.44)

Ref

 

 3-5 cm:

18

32.39 (16.70–48.09)

11

61.11 (38.62–79.69)

6

33.33 (16.28–56.25)

4

22.22 (9.00–45.21)

0.61 (0.35–1.08)

0.09

 5-10 cm:

32

32.22 (19.53–44.91)

18

56.25 (39.33–71.83)

12

37.50 (22.93–54.75)

7

21.88 (11.02–38.75)

0.72 (0.41–1.29)

0.28

  > 10 cm:

34

33.98 (21.33–46.62)

20

58.82 (42.22–73.63)

11

32.35 (19.13–49.16)

7

20.59 (10.35–36.80)

0.73 (0.45–1.20)

0.21

 Unknown:

34

21.88 (13.10–30.65)

      

–

–

Lymph node invasion:

         

0.007

 No:

115

32.72 (26.30–39.30)

71

61.74 (52.61–70.11)

38

33.04 (25.12–42.07)

23

20.00 (13.71–28.23)

Ref

 

 Yes:

12

13.00 (0.54–25.46)

5

41.67 (19.33–68.05)

3

25.00 (8.89–53.23)

1

8.33 (1.49–35.39)

0.89 (0.49–1.63)

0.09

 Unknown:

13

29.58 (3.69–55.48)

      

–

–

Total tumor number:

         

0.27

 1:

92

33.46 (25.89–41.04)

54

58.70 (48.48–68.21)

30

32.61 (23.89–42.72)

20

21.74 (14.54–31.21)

Ref

 

 2:

36

22.19 (14.10–30.29)

20

55.56 (39.58–70.46)

9

25.00 (13.75–41.07)

3

8.33 (2.87–21.83)

2.08 (0.29–14.99)

0.47

 3:

11

32.18 (2.96–61.41)

5

45.45 (21.27–71.99)

2

18.18 (5.14–47.70)

1

9.09 (1.62–37.74)

2.94 (0.40–21.62)

0.29

 4:

1

78.00

1

–

1

–

1

–

2.13 (0.27–16.66)

0.47

AFP:

         

0.12

 Elevated:

12

21.67 (3.82–39.52)

4

33.33 (13.81–60.94)

3

25.00 (8.89–53.23)

3

25.00 (8.89–53.23)

Ref

 

 Normal:

35

40.20 (25.43–54.97)

20

57.14 (40.86–72.02)

14

40.00 (25.55–56.43)

10

28.57 (16.33–45.05)

1.29 (0.70–2.37)

0.41

 Unknown:

93

28.24 (21.86–34.63)

      

–

–

Fibrosis Score

         

0.78

 Fibrosis score 0–4:

13

25.62 (10.57–40.66)

7

53.85 (29.14–76.79)

3

23.08 (8.18–50.26)

2

15.38 (4.33–42.23)

Ref

 

 Fibrosis score 5–6:

2

39.00 (0.00–115.44)

1

–

1

–

1

–

1.21 (0.68–2.15)

0.51

 Unknown:

125

31.12 (24.76–37.49)

      

–

–

Surgery

         

0.00

 Yes:

45

54.16 (42.34–65.98)

40

88.89 (76.50–95.16)

26

57.78 (43.30–71.03)

19

42.22 (28.97–56.70)

Ref

 

 No:

95

19.25 (14.03–24.48)

39

41.05 (31.70–51.10)

16

16.84 (10.64–25.62)

7

7.37 (3.61–14.44)

0.38 (0.26–0.56)

0.00

Chemotherapy:

         

0.34

 Yes:

34

25.68 (15.71–35.64)

18

52.94 (36.74–68.55)

8

23.53 (12.44–40.00)

4

11.76 (4.67–26.62)

Ref

 

 No/unknown:

106

32.43 (25.32–39.54)

61

57.55 (48.04–66.53)

34

32.08 (23.95–41.45)

22

20.75 (14.12–29.43)

1.21 (0.82–1.79)

0.35

Radiation:

         

0.97

 Yes:

4

29.75 (18.09–41.41)

3

75.00 (30.06–95.44)

2

50.00 (15.00–85.00)

0

–

Ref

 

 No/unknown:

136

30.75 (24.69–36.82)

75

55.15 (46.76–63.25)

40

29.41 (22.40–37.55)

26

19.12 (13.39–26.54)

1.02 (0.37–2.77)

0.97

  1. Tumor grade: I: Well differentiated, II: moderately differentiated, III: poorly differentiated, IV: undifferentiated;