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Table 1 Patients characteristics and univariate analysis

From: Development of a nomogram model to predict survival outcomes in patients with primary hepatic neuroendocrine tumors based on SEER database

Variables Survival time Survival number and rate Univariate analysis
Number Mean survival time [95% CI] (months) 1-year survival 3-years survival 5-years survival
Total number 140   Number Rate [95%CI] Number Rate [95%CI] Number Rate [95%CI] HR [95%CI] P-value
Age (years):           0.002
 00–24: 1 16.00 Ref  
 25–49: 28 50.75 (35.20–66.30) 22 78.57 (60.46–89.79) 15 53.57 (35.81–70.47) 9 32.14 (17.93–50.66) 1.04 (0.14–7.58) 0.97
 50–74: 68 30.33 (21.98–38.68) 36 52.94 (41.24–64.33) 22 32.35 (22.44–44.16) 15 22.06 (13.85–33.26) 0.38 (0.23–0.63) 0.00
  > 75: 43 18.05 (10.82–25.28) 20 46.51 (32.51–61.08) 5 11.63 (5.07–24.48) 2 4.65 (1.28–15.46) 0.64 (0.43–0.96) 0.03
Race:           0.20
 black: 24 25.96 (15.72–36.20) 15 62.50 (42.71–78.84) 6 25.00 (12.00–44.90) 3 12.50 (4.34–31.00) Ref  
 other: 9 16.78 (0.92–32.63) 4 44.44 (18.88–73.33) 1 11.11 (1.99–43.50) 1 1.25 (0.79–1.96) 0.34
 white: 107 33.05 (25.82–40.29) 60 56.07 (46.62–65.11) 35 32.71 (24.55–42.06) 22 20.56 (13.99–29.17) 1.73 (0.87–3.43) 0.12
Sex:           0.24
 Female: 85 33.29 (25.58–41.01) 49 57.65 (47.04–67.60) 27 31.76 (22.84–42.27) 18 21.18 (13.84–31.01) Ref  
 Male: 55 26.84 (17.73–35.94) 30 54.55 (41.52–66.97) 15 27.27 (17.28–40.23) 8 14.55 (7.56–26.16) 0.82 (0.58–1.15) 0.25
Marital status:           0.78
 Married: 75 32.57 (23.89–41.25) 45 60.00 (48.69–70.34) 21 28.00 (19.10–39.04) 14 18.67 (11.46–28.93) Ref  
 Unmarried: 26 31.54 (16.84–46.24) 13 50.00 (32.06–67.94) 10 38.46 (22.43–57.47) 6 23.08 (11.03–42.05) 0.87 (0.43–1.76) 0.70
 Separated: 30 25.96 (15.40–36.52) 14 46.67 (30.23–63.86) 9 30.00 (16.66–47.88) 5 16.67 (7.34–33.56) 0.86 (0.40–1.87) 0.71
 Unknown: 9 28.00 (15.45–40.55)    
Insurance:           0.002
 Yes: 105 28.06 (22.56–33.56) 63 60.00 (50.44–68.86) 30 28.57 (20.81–37.85) 18 17.14 (11.13–25.48) Ref  
 No: 8 10.25 (0.00–22.04) 1 12.50 (2.24–47.09) 1 12.50 (2.24–47.09) 0 1.96 (1.18–3.27) 0.009
 unknown 27 48.54 (27.33–69.76)       
Tumor grade:           0.00
 I: 56 47.57 (37.67–57.48) 50 89.29 (78.53–95.00) 28 50.00 (37.33–62.67) 16 28.57 (18.42–41.48) Ref  
 II: 25 41.84 (27.99–55.68) 18 72.00 (52.42–85.72) 11 44.60 (26.67–62.93) 8 32.00 (17.21–51.59) 0.16 (0.08–0.32) 0.00
 III: 47 9.57 (4.66–14.48) 11 23.40 (13.60–37.22) 2 4.26 (1.17–14.25) 1 2.13 (0.38–11.11) 0.20 (0.10–0.41) 0.29
 IV: 12 5.58 (0.00–12.36) 1 8.33 (1.49–35.39) 0 0 0.71 (0.37–1.34) 0.00
 Unknown: 0          
Tumor size:           0.44
  < 3 cm: 22 35.14 (16.93–53.34) 13 59.09 (38.73–76.74) 7 31.82 (16.36–52.68) 5 22.73 (10.12–43.44) Ref  
 3-5 cm: 18 32.39 (16.70–48.09) 11 61.11 (38.62–79.69) 6 33.33 (16.28–56.25) 4 22.22 (9.00–45.21) 0.61 (0.35–1.08) 0.09
 5-10 cm: 32 32.22 (19.53–44.91) 18 56.25 (39.33–71.83) 12 37.50 (22.93–54.75) 7 21.88 (11.02–38.75) 0.72 (0.41–1.29) 0.28
  > 10 cm: 34 33.98 (21.33–46.62) 20 58.82 (42.22–73.63) 11 32.35 (19.13–49.16) 7 20.59 (10.35–36.80) 0.73 (0.45–1.20) 0.21
 Unknown: 34 21.88 (13.10–30.65)       
Lymph node invasion:           0.007
 No: 115 32.72 (26.30–39.30) 71 61.74 (52.61–70.11) 38 33.04 (25.12–42.07) 23 20.00 (13.71–28.23) Ref  
 Yes: 12 13.00 (0.54–25.46) 5 41.67 (19.33–68.05) 3 25.00 (8.89–53.23) 1 8.33 (1.49–35.39) 0.89 (0.49–1.63) 0.09
 Unknown: 13 29.58 (3.69–55.48)       
Total tumor number:           0.27
 1: 92 33.46 (25.89–41.04) 54 58.70 (48.48–68.21) 30 32.61 (23.89–42.72) 20 21.74 (14.54–31.21) Ref  
 2: 36 22.19 (14.10–30.29) 20 55.56 (39.58–70.46) 9 25.00 (13.75–41.07) 3 8.33 (2.87–21.83) 2.08 (0.29–14.99) 0.47
 3: 11 32.18 (2.96–61.41) 5 45.45 (21.27–71.99) 2 18.18 (5.14–47.70) 1 9.09 (1.62–37.74) 2.94 (0.40–21.62) 0.29
 4: 1 78.00 1 1 1 2.13 (0.27–16.66) 0.47
AFP:           0.12
 Elevated: 12 21.67 (3.82–39.52) 4 33.33 (13.81–60.94) 3 25.00 (8.89–53.23) 3 25.00 (8.89–53.23) Ref  
 Normal: 35 40.20 (25.43–54.97) 20 57.14 (40.86–72.02) 14 40.00 (25.55–56.43) 10 28.57 (16.33–45.05) 1.29 (0.70–2.37) 0.41
 Unknown: 93 28.24 (21.86–34.63)       
Fibrosis Score           0.78
 Fibrosis score 0–4: 13 25.62 (10.57–40.66) 7 53.85 (29.14–76.79) 3 23.08 (8.18–50.26) 2 15.38 (4.33–42.23) Ref  
 Fibrosis score 5–6: 2 39.00 (0.00–115.44) 1 1 1 1.21 (0.68–2.15) 0.51
 Unknown: 125 31.12 (24.76–37.49)       
Surgery           0.00
 Yes: 45 54.16 (42.34–65.98) 40 88.89 (76.50–95.16) 26 57.78 (43.30–71.03) 19 42.22 (28.97–56.70) Ref  
 No: 95 19.25 (14.03–24.48) 39 41.05 (31.70–51.10) 16 16.84 (10.64–25.62) 7 7.37 (3.61–14.44) 0.38 (0.26–0.56) 0.00
Chemotherapy:           0.34
 Yes: 34 25.68 (15.71–35.64) 18 52.94 (36.74–68.55) 8 23.53 (12.44–40.00) 4 11.76 (4.67–26.62) Ref  
 No/unknown: 106 32.43 (25.32–39.54) 61 57.55 (48.04–66.53) 34 32.08 (23.95–41.45) 22 20.75 (14.12–29.43) 1.21 (0.82–1.79) 0.35
Radiation:           0.97
 Yes: 4 29.75 (18.09–41.41) 3 75.00 (30.06–95.44) 2 50.00 (15.00–85.00) 0 Ref  
 No/unknown: 136 30.75 (24.69–36.82) 75 55.15 (46.76–63.25) 40 29.41 (22.40–37.55) 26 19.12 (13.39–26.54) 1.02 (0.37–2.77) 0.97
  1. Tumor grade: I: Well differentiated, II: moderately differentiated, III: poorly differentiated, IV: undifferentiated;