Table 2 Associations of SNPs with second primary cancer risk in sixteen cohort studies included in systematic review

G4C14-to-A4T14 (rs2273953 and rs1801173)

p73

1

Li F, 2009 [37]

GC/GC

741 (57.7)

1 (ref.)

GC/AT

484 (37.7)

0.61

0.40

0.93

AT/AT

59 (4.6)

0.44

0.14

1.41

GC/AT + AT/AT

543 (42.3)

0.59

0.39

0.89

Zhang Y, 2012 [27]

GA + AA

530 (41.8)

1 (ref.)

GG

739 (58.2)

1.68

1.12

2.52

GST-M1

GST

1

Zafereo, 2009 [40]

Wild-type

601 (49.6)

1

Null

610 (50.4)

1.4

0.9

2.0

Azad AK, 2012^a [33]

N/A N/A

Absent 274 (52.0); Present 255 (48.0)

1.13

0.78

1.66

Minard CG, 2007 [34]

Nonnull

154 (50.8)

1

Null

149 (49.2)

1.99

1.11

3.56

GSTM1 + GSTT1

GST

1

Zafereo, 2009 [40]

M1 Wild and T1 Wild

470 (38.8)

1

Either M1 Null or T1 Null

621 (51.3)

1.3

0.8

1.9

M1 Null and T1 Null

120 (9.9)

1.6

0.9

3.1

GSTP1_114

GST

1

Zafereo, 2009 [40]

Ala/Ala

1021 (84.4)

1

Ala/Val + Val/Val

189 (15.6)

0.8

0.5

1.5

GST-T1

GST

1

Minard CG, 2006 [34]

Nonnull

249 (82.2)

1

Null

54 (17.8)

0.59

0.25

1.41

Zafereo, 2009 [40]

Wild-type

960 (79.3)

1

Null

251 (20.7)

1.1

0.7

1.8

Azad AK, 2012^a [33]

N/A N/A

Absent 103 (19.0); Present 427 (81.0)

0.95

0.6

1.51

Leu84Phe

MGMT

10

Gal TJ, 2005 [28]

84 AnyPhe

55 (20.1)

0.53

0.28

1.02

rs1042522

P53

17

Azad AK, 2012^a [33]

Arg72Pro C > G

CC 302 (57.0);

CG 196 (37.0);

GG 32 (6.0)

0.78

0.56

1.09

Jin L, 2013 [32]

WW

661 (51.5)

1

WP/PP

622 (48.5)

1.6

1.1

2.4

Li F, 2010 [23]

Arg/Arg (ref)

657 (51.7)

1.00

Arg/Pro

490 (38.5)

1.75

1.17

2.62

Pro/Pro

124 (9.8)

0.93

0.44

1.95

Arg/Pro+Pro/Pro

614 (48.3)

1.58

1.07

2.34

Zhang Y, 2012 [27]

WW

655 (51.6)

1

WP + PP

614 (48.4)

1.58

1.07

2.34

rs1047768

ERCC5

13

Azad AK, 2012^a [33]

C581T T > C

CC 200 (38.0);

CT 256 (48.0);

TT 72 (14.0)

1.08

0.82

1.41

p21 C70T

(rs1059234)

p21

6

Lei D, 2010 [43]

CC

1102 (86.0)

1

CT

164 (12.8)

1.92

1.21

3.05

TT

16 (1.2)

1.06

0.26

4.42

CT + TT

180 (14.0)

1.82

1.16

2.85

Wang Z, 2012 [30]

CC (Ref.c)

706 (54.6)

1

CT + TT

586 (45.4)

1.7

1.1

2.7

rs10900598

MDM4

1

Jin L, 2013 [32]

GT/TT

883 (68.8)

1

GG

400 (31.2)

1.4

1.0

2.1

rs10901431

MMP21

10

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

1.96

1.19

3.33

rs11101992

GSTM5

1

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

2.00

1.23

3.33

rs11244664

BCCIP

10

Lee JJ, 2011 [35]

additive (common genotype model)

NR

1.67

1.16

2.38

rs11602501

TNKS1BP1

11

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

1.96

1.19

3.23

rs11801299

MDM4

1

Jin L, 2013 [32]

GG

835 (65.1)

1

AG/AA

448 (34.9)

1.1

0.7

1.5

rs12137934

RAD54L

1

Lee JJ, 2011 [35]

additive

NR

1.85

1.23

2.78

rs1229984

ADH1B

4

Leoncini E, 2015 [41]

GG

NR

1

GG/GT

NR

0.58

0.28

1.20

rs1243872

CA9

9

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

1.92

1.19

3.13

Lys 751 Gln (rs13181)

XPD (ERCC2)

19

Gal TJ, 2005 [28]

Gln/Gln

37 (13.4)

0.74

0.32

1.72

Lys/Gln

127 (46.0)

1.19

0.73

1.94

AnyGln

164 (59.4)

1.09

0.68

1.73

Azad AK, 2012^a [33]

Lys751Gln A > C

TT 241 (45);

TG 232 (44);

GG 57 (11)

0.91

0.69

1.20

Zafereo, 2009 [39]

Lys/Lys and Lys/Gln

1126 (88.0)

1

Gln/Gln

154 (12.0)

1.1

0.6

1.9

rs1380576

MDM4

1

Jin L, 2013 [32]

CC

547 (42.6)

1

CG/GG

736 (57.4)

1.1

0.8

1.6

rs1410280

CDK8

13

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

4.35

1.49

12.50

rs1573496

ADH7

4

Leoncini E, 2015 [41]

CC

NR

1

CG/GG

NR

1.25

0.75

2.08

GSTP1_105 (rs1695)

GST

1

Zafereo, 2009 [40]

Ile/Ile

484 (40.1)

1

Ile/Val + Val/Val

723 (59.9)

1.7

1.1

2.5

His1104Asp (rs17655)

ERCC5 (XPG)

13

Azad AK, 2012^a [33]

His1104Asp G > C

CC 200 (38);

CT 256 (48);

TT 72 (14)

0.94

0.69

1.28

Zafereo, 2009 [39]

His/His and His/Asp

819 (95.6)

1

Asp/Asp

38 (4.4)

1.1

0.4

2.6

Asp312Asn (rs1799793)

XPD (ERCC2)

19

Azad AK, 2012^a [33]

Asp312Asn G > A

GG 243 (46);

GA 231 (44);

AA 54 (10)

1.05

0.80

1.40

Zafereo, 2009 [39]

Asp/Asp and Asp/Asn

1086 (87.2)

1

Asn/Asn

160 (12.8)

0.7

0.4

1.4

Ala499Val (rs2228000)

XPC

3

Zafereo. 2009 [39]

Ala/Ala and Ala/Val

757 (90.2)

1

Val/Val

82 (9.8)

0.7

0.4

1.4

rs1799801

ERCC4

16

Azad AK, 2012^a [33]

T2505C T > C

TT 255 (48);

TC 226 (43);

CC 47 (9)

1.05

0.79

1.39

FAS -670A > G (rs1800682)

FAS

10

Lei D, 2010 [25]

AA

333 (25.9)

1

AG + GG

953 (74.1)

1.57

1.00

2.54

AA ref. (OPC)

7

1.0

AG + GG (OPC)

35

2.2

0.9

5.3

Sun Y, 2016 [29]

AA ref. (non_OPC)

13

1.0

AG + GG (non_OPC)

69

2.4

1.1

5.1

rs1800975 (G23A)

XPA

9

Azad AK, 2012^a [33]

50UTR A > G

GG 209 (40);

GA 262 (50);

AA 58 (10)

1.08

0.81

1.44

Zafereo, 2009 [39]

GG + GA

767 (86.3)

1

AA

122 (13.7)

0.7

0.4

1.3

P21 C98A (rs1801270)

P21

6

Wang Z, 2012 [30]

CC (Ref.c)

1.105 (85.5)

1

CA + AA

187 (14.5)

1.7

1.1

2.6

Lei D, 2010 [43]

CC

1095 (85.4)

1

CA

168 (13.1)

1.81

1.14

2.87

CA + AA

19 (1.5)

1.8

1.14

2.82

AA

187 (14.6)

1.71

0.41

7.03

rs1887427

JAK2

9

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

2.33

1.41

3.85

P27 T109G (rs2066827)

P27

12

Wang Z, 2012 [30]

TT (Ref.c)

706 (54.6)

1

TG + GG

586 (45.4)

2.0

1.5

3.1

Lys939Gln (rs2228000)

XPC

3

Zafereo, 2009 [39]

Lys/Lys and Lys/Gln

821 (85.6)

1

Gln/Gln

138 (14.4)

0.9

0.5

1.5

rs2233913

SLC31A1

9

Lee JJ 2011 [35]

dominant (common genotype model)

NR

3.03

1.39

6.67

FAS −1377 (G > A) (rs2234767)

FAS

10

Lei D, 2010 [25]

GG

1.023 (79.6)

1

GA + AA

263 (20.4)

0.87

0.56

1.36

GG ref. (OPC-HNC)

34

1.0

AG + AA (OPC-HNC)

8

0.8

0.4

1.9

Sun Y, 2016 [29]

GG ref. (non-OPC-HNC)

64

1.0

AG + AA (non-OPC-HNC)

18

1.0

0.5

1.8

rs2273953

p73

1

Jin L, 2013 [32]

GA/AA

746 (58.1)

1

GG

537 (41.9)

1.5

1.0

2.2

rs2274471

JAK2

9

Lee JJ, 2011 [35]

additive

NR

1.79

1.18

2.70

rs2279744

MDM2

12

Jin L, 2013 [32]

TT

741 (57.7)

1

GT/GG

542 (42.3)

1.9

1.2

2.7

rs2303426

MSH2

2

Azad AK, 2012^a [33]

C211þ9G G > C

CC 214 (41);

GC 251 (48);

GG 56 (11)

0.89

0.67

1.19

Val143Ile

MGMT

10

Gal TJ, 2005 [28]

143 Any Ile

66 (24.2)

1.10

0.66

1.85

rs231775

CTLA4

2

Azad AK, 2012^a [33]

A49G A > G

AA 247 (47);

AG 221 (42);

GG 62 (11)

1.03

0.78

1.37

rs2424913

DNMT3B

20

Azad AK, 2012^a [33]

C149T C > T

CC 183 (35);

CT 247 (47);

TT 96 (18)

1.49

1.15

1.95

Arg 399 Gln (rs25487)

XRCC1

19

Azad AK, 2012^a [33]

Arg399Gln A > G

CC 222 (42);

CT 235 (44);

TT 73 (14)

1.17

0.89

1.54

Gal TJ, 2005 [28]

Gln/Gln

25 (9.4)

1.56

0.73

3.45

Any Gln

142 (53.2)

0.87

0.55

1.39

Arg/Gln

117 (43.8)

0.79

0.48

1.29

rs3025090

MMP3

11

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

3.57

1.64

7.69

rs3088440

p14ARF

9

Jin L. 2013 [32]

GG

1034 (80.6)

1

GA/AA

249 (19.4)

1.6

1.1

2.4

Zhang Y, 2011 [31]

GG (Ref.c)

1038 (80.7)

1.0

1

GA

219 (17.0)

1.69

1.11

2.56

AA

30 (2.3)

1.05

0.33

3.37

GA + AA

249 (19.3)

1.61

1.07

2.43

rs3118570

RXRA

9

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

3.33

1.67

6.67

rs3212986 (C8092A)

ERCC1

19

Zafereo, 2009 [39]

CC + CA

1000 (93.7)

1

AA

67 (6.3)

0.9

0.4

1.9

Azad AK, 2012^a [33]

C8092A C > A

CC 320 (60);

AC 179 (34);

AA 31 (6)

1.06

0.77

1.46

rs35068180

MMP3

11

Azad AK, 2012^a [33]

1612insA −/A

5A/5A 128 (24); 5A/6A 275 (53); 6A/6A 122 (23)

1.01

0.76

1.34

rs351855

FGFR4

5

Azad AK, 2012^a [33]

Gly388Arg G > A

CC 281 (53);

CT 210 (40);

TT 37 (7)

0.98

0.73

1.32

rs35742686

CYP2D6

22

Azad AK, 2012^a [33]

DelA

AA 441 (87);

GA 63 (12);

GG 1 (1)

0.83

0.48

1.43

rs3731217

p14ARF

9

Jin L, 2013 [32]

TT

963 (75.1)

1

TG/GG

320 (24.9)

1.5

1.0

2.3

Zhang Y, 2011 [31]

TT (Ref.c)

966 (75.1)

1.00

1

TG

293 (22.8)

1.54

1.03

2.31

GG

28 (2.1)

0.82

0.20

3.35

TG + GG

321 (24.9)

1.48

1.00

2.19

rs3827665

TSC1

9

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

3.57

1.41

9.09

rs3892097

CYP2D6

22

Azad AK, 2012^a [33]

G > A

GG 281 (56);

GA 198 (39);

AA 25 (5)

1.09

0.78

1.51

FASLG −124 A > G (rs5030772)

FASLG

1

Lei D, 2010 [25]

AA

981 (76.3)

1

AG + GG

305 (23.7)

1.15

0.75

1.77

Sun Y, 2016 [29]

AA ref. (non-OPC-HNC)

63

1

AG + GG (non-OPC-HNC)

19

1.6

0.9

3.0

AA ref. (OPC-HNC)

31

1

AG + GG (OPC-HNC)

11

1.1

0.5

2.4

rs603965

CCND1

11

Azad AK, 2012^a [33]

A870G G > A

GG 138 (26);

GA 258 (49);

AA 132 (25)

1.06

0.82

1.38

rs6596428

CDC25C

5

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

2.08

1.28

3.45

rs678653

CCND1

11

Azad AK, 2012^a [33]

G1722C C > G

GG 229 (44);

GC 230 (44);

CC 66 (12)

0.73

0.54

0.99

rs7040593

TSC1

9

Lee JJ, 2011 [25]

dominant (common genotype model)

NR

3.03

1.37

6.67

rs735482

ERCC1

19

Azad AK, 2012^a [33]

Lys259Thr A > C

AA 409 (78);

CA 111 (21);

CC 6 (1)

0.94

0.62

1.44

rs739442

TSC1

9

Lee JJ, 2011 [35]

additive

NR

1.56

1.12

2.17

FASLG -844C > T (rs763110)

FASL

1

Lei D, 2010 [25]

CC

511 (39.7)

1

CT + TT

775 (60.3)

1.71

1.15

2.54

Sun Y, 2016 [29]

CC ref. (non-OPC-HNC)

26

1

CT + TT (non-OPC-HNC)

56

1.7

1.0

3.0

CC ref. (OPC-HNC)

11

1

CT + TT (OPC-HNC)

31

2.7

1.2

6.0

rs937283

MDM2

12

Jin L, 2013 [32]

AA

343 (26.7)

1

AG/GG

940 (73.7)

1.2

0.8

1.8

Thr 241 Met (rs861539)

XRCC3

14

Azad AK, 2012^a [33]

Thr241Met C > T

GG 189 (36);

AG 251 (47);

AA 90 (17)

1.00

0.77

1.31

Gal TJ, 2005 [28]

Any Met

149 (58.4)

1.62

0.98

2.67

Thr/Met

111 (43.5)

1.38

0.81

2.37

Met/Met

38 (14.9)

2.65

1.29

5.45

rs9551427

FLT3

13

Lee JJ, 2011 [35]

dominant (common genotype model)

NR

1.92

1.19

3.13