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Table 3 Distribution of imputed ABO blood typesa and the risk of upper gastrointestinal cancer

From: ABO genotypes and the risk of esophageal and gastric cancers

Group Total Blood Type
N O A B AB
Number of controls (%) 2696 889 (33.0%) 725 (26.9%) 853 (31.6%) 229 (8.5%)
Number of ESCC cases (%) 2022 581 (28.8%) 527 (26.1%) 701 (34.8%) 208 (10.3%)
Crudeb OR (95% CI)   REF 1.18 (1.00–1.38) 1.21 (1.04–1.41) 1.35 (1.08–1.69)
Adjustedc OR (95% CI)   REF 1.17 (1.00–1.38) 1.19 (1.02–1.38) 1.34 (1.07–1.67)
Number of Cardia cases (%) 1189 362 (30.7%) 321 (27.2%) 383 (32.4%) 115 (9.7%)
Crudeb OR (95% CI)   REF 1.12 (0.94–1.35) 1.06 (0.89–1.26) 1.19 (0.92–1.55)
Adjustedc OR (95% CI)   REF 1.13 (0.94–1.36) 1.07 (0.89–1.27) 1.17 (0.90–1.53)
Number of Noncardia cases (%) 1161 339 (29.3%) 375 (32.4%) 330 (28.5%) 113 (9.8%)
Crudeb OR (95% CI)   REF 1.38 (1.15–1.66) 1.13 (0.94–1.36) 1.47 (1.12–1.91)
Adjustedc OR (95% CI)   REF 1.37 (1.14–1.65) 1.12 (0.93–1.35) 1.44 (1.10–1.89)
  1. aBlood types imputed from genotype data at rs505922, rs8176746, and rs574347
  2. bCrude logistic models stratified on study
  3. cStudy stratified models adjusted for age, sex, alcohol consumption, and ever smoking tobacco