Fig. 6

PDE9A promoter methylation profile based on different variables of TCGA colon adenocarcinoma (COAD) from UALCAN database. The variables are (a) sample types, (b) individual cancer stages, (c) patient’s race, (d) patient’s gender, (e) patient’s age, (f) patient’s weight, (g) nodal metastasis status, (h) histological subtype, and (i) TP53 mutation status. According to UALCAN, the Beta value indicates the level of DNA methylation ranging from 0 (unmethylated) to 1 (fully methylated). Different beta value cut-off has been considered to indicate hypermethylation [Beta value: 0.7–0.5] or hypo-methylation [Beta-value: 0.3–0.25]