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Table 2 Overall best response per RECIST Ver1.1. by ALDH2 genotype

From: ALDH2 polymorphism rs671 is a predictor of PD-1/PD-L1 inhibitor efficacy against thoracic malignancies

 

Total

Rs671(−)

Rs671(+)

p

Best response to immune checkpoint inhibitor

 Complete response

0

(0%)

0

(0%)

0

(0%)

0.0022

 Partial response

33

(31%)

20

(36%)

13

(27%)

 

 Stable disease

42

(40%)

28

(50%)

14

(29%)

 

 Progressive disease

30

(29%)

8

(14%)

22

(45%)

 

Disease control rate

71%

 

86%

 

55%

 

0.0005

  1. N = 105. Rs671(−); ALDH2*1/*1, rs671(+); ALDH2*1/*2 or ALDH2*2/*2, disease control rate; (all − progressive disease)/all, p probability value for Chi-squared test