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Fig. 4 | BMC Cancer

Fig. 4

From: ALDH2 polymorphism rs671 is a predictor of PD-1/PD-L1 inhibitor efficacy against thoracic malignancies

Fig. 4

Hazard ratio of cancer progression by ALDH2 genotype estimated from the entire observation period. Rs671(−); ALDH2*1/*1, rs671(+); ALDH2*1/*2 or ALDH2*2/*2. Hazard ratio and 95% confidence interval (error bar) was estimated by the Cox proportional hazard model includes all explanatory covariates shown in this figure. ICI; immune checkpoint inhibitor, PD-L1; programmed death-ligand 1, EGFR; epidermal growth factor receptor, p-value for interactions was estimated by the model including all covariates shown above, rs671, and interaction in terms of sex*rs671, type of ICI*rs671, treatment line*rs671, PD-L1 ratio*rs671, and EGFR mutation*rs671. P values are shown separately for each genotype with forest plot if p < 0.2. All p values for interaction are shown on the right

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