Fig. 1

The expression of EGFL8 in HCC tissues and its association with prognosis of HCC patients. a The reverse transcription-quantitative polymerase chain reaction (RT-qPCR) results obtained from 102 cases of HCC tissues and matched ANLTs showed that EGFL8 mRNA expression was down-regulated in HCC tissues (the long bar in this figure represents median and the short bars represent 25 and 75% percentiles of the expressions of EGFL8). ***, P < 0.001. b The representative Western blot results showed that Egfl8 protein in HCC tissues was significantly lower than those in ANLTs (the long bar in this figure represents median and the short bars represent 25 and 75% percentiles of the expressions of EGFL8). T, HCC tissues; N, ANLTs; ***, P < 0.001. c Estimated overall survival according to the expression of EGFL8 mRNA in 102 cases of HCC tissues (the Kaplan-Meier method). Log-Rank test shows that HCC patients within low EGFL8 expression group had poorer overall survival than those in high EGFL8 expression group (P = 0.0140). d Progression free survival was analyzed in the same cohort of HCC patients and the results showed that HCC patients in low EGFL8 expression group also had poorer progression free survival than those in high EGFL8 expression group (P = 0.0465)