Table 3 HRs for comparison of time to worsening of EORTC QLQ-C30 scale scores by depth of response and MRD status for pooled treatment arms

GHS

0.72 (0.54–0.96)

0.025

1.75 (1.16–2.66)

0.008

0.70 (0.50–0.99)

0.042

Physical functioning

0.88 (0.66–1.17)

0.365

1.60 (0.05–2.45)

0.031

0.79 (0.57–1.10)

0.168

Role functioning

0.93 (0.72–1.20)

0.578

1.55 (1.05–2.27)

0.027

0.84 (0.62–1.12)

0.235

Emotional functioning

0.79 (0.57–1.07)

0.120

1.87 (1.21–2.88)

0.005

0.93 (0.66–1.31)

0.680

Cognitive functioning

0.81 (0.64–1.02)

0.075

1.28 (0.88–1.85)

0.200

1.02 (0.78–1.32)

0.910

Social functioning

0.87 (0.67–1.13)

0.290

1.50 (1.01–2.23)

0.044

0.89 (0.66–1.21)

0.453

Pain

0.72 (0.56–0.94)

0.017

1.22 (0.81–1.86)

0.340

0.60 (0.43–0.83)

0.002

Fatigue

1.01 (0.88–1.29)

0.950

1.44 (0.99–2.10)

0.060

0.98 (0.74–1.29)

0.023

Nausea/vomiting

1.05 (0.80–1.39)

0.733

1.38 (0.88–2.16)

0.158

0.92 (0.67–1.27)

0.610

Dyspnea

0.64 (0.48–0.84)

0.002

1.42 (0.94–2.15)

0.096

0.71 (0.51–0.98)

0.037

Insomnia

0.80 (0.62–1.04)

0.099

1.26 (0.84–1.90)

0.265

0.83 (0.61–1.12)

0.215

Appetite loss

1.05 (0.80–1.39)

0.716

1.67 (1.10–2.55)

0.017

0.96 (0.71–1.31)

0.596

Constipation

0.80 (0.61–1.06)

1.127

1.30 (0.84–2.02)

0.233

0.92 (0.67–1.26)

0.596

Diarrhea

1.03 (0.77–1.38)

0.832

1.39 (0.87–2.24)

0.172

0.89 (0.63–1.24)

0.475