Evaluation of functional outcome of bilateral kidney tumors after sequential surgery

BMC Cancer

Table 5 Multivariate Cox regression analyses of variables associated with de novo CKD within postoperative one year

	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95% CI	P value
Age (years)	1.032	1.009–1.056	0.001	1.036	1.011–1.062	0.005
BMI	1.011	0.924–1.106	0.810
Sex, male	0.711	0.348–1.454	0.350
DM	1.295	0.646–2.595	0.466
HTN	2.413	1.353–4.304	0.003	2.159	1.233–3.783	0.007
Baseline eGFR	0.992	0.982–1.003	0.150
Baseline Hb	0.986	0.875–1.112	0.822
EBL (1st surgery)	1.000	0.999–1.001	0.799
EBL (2nd surgery)	1.000	0.999–1.001	0.663
Ischemic time (1st surgery)	1.005	0.974–1.037	0.763
Ischemic time (2nd surgery)	0.987	0.957–1.019	0.431
Pathologic tumor size (1st surgery)	1.015	1.006–1.024	0.001	1.012	1.003–1.021	0.010
Pathologic tumor size (2nd surgery)	1.004	0.996–1.011	0.326
Time between operations	1.000	1.000–1.001	0.083
Surgery sequence
PN ➔ PN	Reference			Reference
PN ➔ RN	2.249	1.088–4.786	0.006	1.837	1.028–3.635	0.007
RN ➔ PN	1.510	1.096–5.750	0.030	1.235	0.947–5.276	0.066
PN (unilateral case)	0.663	0.285–1.543	0.341	0.315	0.119–0.832	0.261
Tumor chronology
Synchronous	Reference
Metachronous	1.370	0.660–2.840	0.398
Tumor multiplicity
Unilateral	Reference
Bilateral	1.244	0.698–2.215	0.459

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