Skip to main content

Table 4 Multivariable analysis of death in the out-of-landmark population

From: Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of 6 randomized trials

 

Out-of-landmark population

(731 events / 957 patients)

HRa

(95% CI)

P

Worst grade of neutropenia

  

< 0.001

 Grade 1–2 vs 0

0.51

(0.40–0.66)

 

 Grade 3–4 vs 0

0.64

(0.50–0.81)

 

Age (continuous)

1.00

(0.99–1.01)

0.837

Gender

 Female vs Male

0.70

(0.57–0.85)

< 0.001

Performance status

 2 vs 0–1

1.48

(0.85–2.58)

0.164

Stage

 IV vs IIIB

1.38

(1.06–1.79)

0.017

Histology

  

0.925

 Non squamous vs Squamous

0.90

(0.73–1.09)

 

 Undefined vs Squamous

1.01

(0.80–1.28)

 
  1. aStratified by treatment arm and number of cycles