Patient and clinical characteristics | |||
---|---|---|---|
Patients whose miRNA samples were sequenced | All patients (n = 60) | ||
Non-nephrotoxicity group (n = 6) | Nephrotoxicity group (n = 6) | ||
Age (mean ± SD, years) | 60.3 ± 4.9 | 57.5 ± 7.4 | 58.4 ± 7.3 |
Gender (n, %) | |||
Men | 5 (83.3) | 4 (66.7) | 54 (90.0) |
Women | 1 (16.7) | 2 (33.3) | 6 (10.0) |
Ethnicity (n, %) | |||
Caucasian | 4 (66.7) | 6 (100.0) | 45 (75.0) |
Non-Caucasian | 2 (33.3) | 0 (0.0) | 15 (25.0) |
Smoking category (n, %) | |||
Never smoked | 1 (16.7) | 1 (16.7) | 6 (10.0) |
Light smoker | 0 (0.0) | 0 (0.0) | 3 (5.0) |
Moderate smoker | 0 (0.0) | 1 (16.7) | 4 (6.7) |
Heavy smoker | 5 (100.0) | 4 (66.6) | 47 (78.3) |
Drinking category (n, %) | |||
Abstainer | 2 (33.3) | 2 (33.3) | 9 (15.0) |
Light drinker | 0 (0.0) | 0 (0.0) | 5 (8.3) |
Moderate drinker | 0 (0.0) | 0 (0.0) | 2 (3.3) |
Heavy drinker | 3 (50.0) | 1 (16.7) | 16 (26.7) |
Very heavy drinker | 1 (16.7) | 3 (50.0) | 28 (46.7) |
KPS (n, %) | |||
60 | 0 (0.0) | 0 (0.0) | 1 (1.7) |
70 | 0 (0.0) | 0 (0.0) | 1 (1.7) |
80 | 2 (33.3) | 3 (50.0) | 9 (15.0) |
90 | 4 (66.7) | 3 (50.0) | 40 (66.6) |
100 | 0 (0.0) | 0 (0.0) | 9 (15.0) |
Tumor site (n, %) | |||
Oropharynx | 0 (0.0) | 1 (16.7) | 15 (25.0) |
Hypopharynx | 2 (33.3) | 3 (50.0) | 9 (15.0) |
Larynx | 1 (16.7) | 1 (16.7) | 13 (21.7) |
Oral cavity | 3 (50.0) | 1 (16.7) | 20 (33.3) |
Hypopharynx + Larynx | 0 (0.0) | 0 (0.0) | 1 (1.7) |
na | 0 (0.0) | 0 (0.0) | 2 (3.3) |
Stage (n, %) | |||
I | 0 (0.0) | 0 (0.0) | 0 (0.0) |
II | 0 (0.0) | 0 (0.0) | 6 (10.0) |
III | 1 (16.7) | 0 (0.0) | 7 (11.6) |
IV | 5 (83.3) | 6 (100.0) | 46 (76.7) |
na | 0 (0.0) | 0 (0.0) | 1 (1.7) |
Nephrotoxicity parameters | |||
Serum creatinine, SCr (mg/dL) | |||
Baseline | 0.94 ± 0.18 | 0.75 ± 0.10 | 0.82 ± 0.20 |
D5 | 0.94 ± 0.21 | 3.39 ± 2.13 | 1.36 ± 1.01 |
Creatinine clearance (mL/min) | |||
Baseline | 70.20 ± 22.93 | 97.62 ± 40.55 | 87.70 ± 26.90 |
D5 | 69.72 ± 24.01 | 25.05 ± 11.46 | 61.86 ± 25.54 |
Blood urea nitrogen, BUN (mg/dL) | |||
Baseline | 38.50 ± 14.28 | 21.33 ± 9.48 | 28.75 ± 10.95 |
D5 | 45.67 ± 14.88 | 92.00 ± 40.61 | 53.63 ± 22.99 |