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Table 1 Patients with head and neck cancer treated with cisplatin. KPS Karnofsky performance status, SD standard deviation

From: MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer

Patient and clinical characteristics

 

Patients whose miRNA samples were sequenced

All patients (n = 60)

Non-nephrotoxicity group (n = 6)

Nephrotoxicity group (n = 6)

Age (mean ± SD, years)

60.3 ± 4.9

57.5 ± 7.4

58.4 ± 7.3

Gender (n, %)

 Men

5 (83.3)

4 (66.7)

54 (90.0)

 Women

1 (16.7)

2 (33.3)

6 (10.0)

Ethnicity (n, %)

 Caucasian

4 (66.7)

6 (100.0)

45 (75.0)

 Non-Caucasian

2 (33.3)

0 (0.0)

15 (25.0)

Smoking category (n, %)

 Never smoked

1 (16.7)

1 (16.7)

6 (10.0)

 Light smoker

0 (0.0)

0 (0.0)

3 (5.0)

 Moderate smoker

0 (0.0)

1 (16.7)

4 (6.7)

 Heavy smoker

5 (100.0)

4 (66.6)

47 (78.3)

Drinking category (n, %)

 Abstainer

2 (33.3)

2 (33.3)

9 (15.0)

 Light drinker

0 (0.0)

0 (0.0)

5 (8.3)

 Moderate drinker

0 (0.0)

0 (0.0)

2 (3.3)

 Heavy drinker

3 (50.0)

1 (16.7)

16 (26.7)

 Very heavy drinker

1 (16.7)

3 (50.0)

28 (46.7)

KPS (n, %)

 60

0 (0.0)

0 (0.0)

1 (1.7)

 70

0 (0.0)

0 (0.0)

1 (1.7)

 80

2 (33.3)

3 (50.0)

9 (15.0)

 90

4 (66.7)

3 (50.0)

40 (66.6)

 100

0 (0.0)

0 (0.0)

9 (15.0)

Tumor site (n, %)

 Oropharynx

0 (0.0)

1 (16.7)

15 (25.0)

 Hypopharynx

2 (33.3)

3 (50.0)

9 (15.0)

 Larynx

1 (16.7)

1 (16.7)

13 (21.7)

 Oral cavity

3 (50.0)

1 (16.7)

20 (33.3)

 Hypopharynx + Larynx

0 (0.0)

0 (0.0)

1 (1.7)

 na

0 (0.0)

0 (0.0)

2 (3.3)

Stage (n, %)

 I

0 (0.0)

0 (0.0)

0 (0.0)

 II

0 (0.0)

0 (0.0)

6 (10.0)

 III

1 (16.7)

0 (0.0)

7 (11.6)

 IV

5 (83.3)

6 (100.0)

46 (76.7)

 na

0 (0.0)

0 (0.0)

1 (1.7)

Nephrotoxicity parameters

Serum creatinine, SCr (mg/dL)

  Baseline

0.94 ± 0.18

0.75 ± 0.10

0.82 ± 0.20

  D5

0.94 ± 0.21

3.39 ± 2.13

1.36 ± 1.01

Creatinine clearance (mL/min)

  Baseline

70.20 ± 22.93

97.62 ± 40.55

87.70 ± 26.90

  D5

69.72 ± 24.01

25.05 ± 11.46

61.86 ± 25.54

Blood urea nitrogen, BUN (mg/dL)

  Baseline

38.50 ± 14.28

21.33 ± 9.48

28.75 ± 10.95

  D5

45.67 ± 14.88

92.00 ± 40.61

53.63 ± 22.99