|
Patient and clinical characteristics
|
|---|
| |
Patients whose miRNA samples were sequenced
|
All patients (n = 60)
|
|---|
|
Non-nephrotoxicity group (n = 6)
|
Nephrotoxicity group (n = 6)
|
|---|
|
Age (mean ± SD, years)
|
60.3 ± 4.9
|
57.5 ± 7.4
|
58.4 ± 7.3
|
|
Gender (n, %)
|
|
Men
|
5 (83.3)
|
4 (66.7)
|
54 (90.0)
|
|
Women
|
1 (16.7)
|
2 (33.3)
|
6 (10.0)
|
|
Ethnicity (n, %)
|
|
Caucasian
|
4 (66.7)
|
6 (100.0)
|
45 (75.0)
|
|
Non-Caucasian
|
2 (33.3)
|
0 (0.0)
|
15 (25.0)
|
|
Smoking category (n, %)
|
|
Never smoked
|
1 (16.7)
|
1 (16.7)
|
6 (10.0)
|
|
Light smoker
|
0 (0.0)
|
0 (0.0)
|
3 (5.0)
|
|
Moderate smoker
|
0 (0.0)
|
1 (16.7)
|
4 (6.7)
|
|
Heavy smoker
|
5 (100.0)
|
4 (66.6)
|
47 (78.3)
|
|
Drinking category (n, %)
|
|
Abstainer
|
2 (33.3)
|
2 (33.3)
|
9 (15.0)
|
|
Light drinker
|
0 (0.0)
|
0 (0.0)
|
5 (8.3)
|
|
Moderate drinker
|
0 (0.0)
|
0 (0.0)
|
2 (3.3)
|
|
Heavy drinker
|
3 (50.0)
|
1 (16.7)
|
16 (26.7)
|
|
Very heavy drinker
|
1 (16.7)
|
3 (50.0)
|
28 (46.7)
|
|
KPS (n, %)
|
|
60
|
0 (0.0)
|
0 (0.0)
|
1 (1.7)
|
|
70
|
0 (0.0)
|
0 (0.0)
|
1 (1.7)
|
|
80
|
2 (33.3)
|
3 (50.0)
|
9 (15.0)
|
|
90
|
4 (66.7)
|
3 (50.0)
|
40 (66.6)
|
|
100
|
0 (0.0)
|
0 (0.0)
|
9 (15.0)
|
|
Tumor site (n, %)
|
|
Oropharynx
|
0 (0.0)
|
1 (16.7)
|
15 (25.0)
|
|
Hypopharynx
|
2 (33.3)
|
3 (50.0)
|
9 (15.0)
|
|
Larynx
|
1 (16.7)
|
1 (16.7)
|
13 (21.7)
|
|
Oral cavity
|
3 (50.0)
|
1 (16.7)
|
20 (33.3)
|
|
Hypopharynx + Larynx
|
0 (0.0)
|
0 (0.0)
|
1 (1.7)
|
|
na
|
0 (0.0)
|
0 (0.0)
|
2 (3.3)
|
|
Stage (n, %)
|
|
I
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
|
II
|
0 (0.0)
|
0 (0.0)
|
6 (10.0)
|
|
III
|
1 (16.7)
|
0 (0.0)
|
7 (11.6)
|
|
IV
|
5 (83.3)
|
6 (100.0)
|
46 (76.7)
|
|
na
|
0 (0.0)
|
0 (0.0)
|
1 (1.7)
|
|
Nephrotoxicity parameters
|
|
Serum creatinine, SCr (mg/dL)
|
|
Baseline
|
0.94 ± 0.18
|
0.75 ± 0.10
|
0.82 ± 0.20
|
|
D5
|
0.94 ± 0.21
|
3.39 ± 2.13
|
1.36 ± 1.01
|
|
Creatinine clearance (mL/min)
|
|
Baseline
|
70.20 ± 22.93
|
97.62 ± 40.55
|
87.70 ± 26.90
|
|
D5
|
69.72 ± 24.01
|
25.05 ± 11.46
|
61.86 ± 25.54
|
|
Blood urea nitrogen, BUN (mg/dL)
|
|
Baseline
|
38.50 ± 14.28
|
21.33 ± 9.48
|
28.75 ± 10.95
|
|
D5
|
45.67 ± 14.88
|
92.00 ± 40.61
|
53.63 ± 22.99
|
