Fig. 5
From: Co-relation with novel phosphorylation sites of IκBα and necroptosis in breast cancer cells
Phosphorylation of Ser-63 and 262 of IκBα plays a crucial role in necroptosis. FACs-annexin V-staining was performed to measure apoptosis in MDA-MB 231. a Compared with the control group, the distribution of early and late apoptosis was increased and the distribution of necrosis was increased in S63A and S262A (NC vs *p < 0.05, **p < 0.001). b Compared with the control group, expression of phospho-MLKL and phospho-RIP3 was increased in S63A and S262A, and expression of cleaved caspase 3 and caspase 8 was also increased