Skip to main content

Table 4 Cox’s regression analysis for PFS and OS

From: Clinical significance of the cachexia index in patients with small cell lung cancer

Factor

PFS

OS

Univariate

Multivariate

Univariate

Multivariate

HR

95% CI

p

HR

95% CI

p

HR

95% CI

p

HR

95% CI

p

Limited-stage

 Age

   < 70 years

Ref.

     

Ref.

     

   ≥ 70 years

1.147

0.742–1.774

0.537

   

1.343

0.848–2.125

0.208

   

 ECOG PS

  0–1

Ref.

  

Ref.

  

Ref.

  

Ref.

  

  2–3

1.821

1.047–3.167

0.034

1.329

0.730–2.421

0.352

2.108

1.192–3.730

0.010

1.579

0.855–2.915

0.144

 Smoking

  Never-smoker

Ref.

     

Ref.

     

  Current/former smoker

1.697

0.235–12.279

0.600

   

1.587

0.219–11.506

0.648

   

 Regimen

  Etoposide and platinum

Ref.

  

Ref.

  

Ref.

  

Ref.

  

  Irinotecan and cisplatin

8.175

1.063–62.881

0.044

4.553

0.567–36.536

0.154

12.525

1.566–100.158

0.017

7.415

0.887–61.945

0.064

 BMI

  Other (≥ 18.5 kg/m2)

Ref.

     

Ref.

     

  Underweight (<  18.5 kg/m2)

1.328

0.639–2.762

0.447

   

1.121

0.514–2.444

0.774

   

 CXI

  High

Ref.

  

Ref.

  

Ref.

  

Ref.

  

  Low

2.768

1.671–4.587

<  0.001

2.445

1.406–4.253

0.002

2.830

1.698–4.717

<  0.001

2.393

1.372–4.174

0.002

Extensive-stage

 Age

   < 70 years

Ref.

     

Ref.

     

   ≥ 70 years

1.088

0.786–1.506

0.612

   

1.297

0.906–1.855

0.155

   

 ECOG PS

  0–1

Ref.

  

Ref.

  

Ref.

  

Ref.

  

  2–3

2.083

1.435–3.023

<  0.001

1.819

1.236–2.679

0.002

3.152

2.121–4.684

<  0.001

2.768

1.847–4.149

<  0.001

 Smoking

  Never-smoker

Ref.

     

Ref.

     

  Current/former smoker

1.071

0.264–4.344

0.924

   

0.989

0.244–4.016

0.988

   

 Regimen

  Etoposide and platinum

Ref.

     

Ref.

     

  Irinotecan and cisplatin

0.819

0.471–1.426

0.481

   

0.779

0.434–1.396

0.401

   

 BMI

  Other (≥ 18.5 kg/m2)

Ref.

     

Ref.

     

  Underweight (<  18.5 kg/m2)

1.243

0.775–1.994

0.367

   

1.052

0.631–1.754

0.847

   

 CXI

  High

Ref.

  

Ref.

  

Ref.

  

Ref.

  

  Low

2.039

1.401–2.967

<  0.001

1.764

1.195–2.604

0.004

2.644

1.796–3.894

< 0.001

2.269

1.529–3.366

<  0.001

  1. PFS progression-free survival, OS overall survival, HR hazard ratio, CI confidence interval, ECOG PS Eastern Cooperative Oncology Group performance status, BMI body mass index, CXI cachexia index
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us