Table 3 Endometrioid endometrial carcinoma, FIGO stage I-III. Uni- and multivariable Cox proportional hazard regression analyzing overall survival including type of surgery, FIGO grade, FIGO stage, ploidy, lymphovascular space invasion and age
Variables | No. of patients | Univariable Cox regression | Multivariable Cox regression | ||
|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | ||
Surgical approach | |||||
MIS | 2310 | Ref. | Ref. | ||
Open surgery | 1950 | 1.33 (1.10–1.61) | 0.003 | 1.12 (0.93–1.36) | 0.24 |
FIGO gradea | |||||
1–2 | 3621 | Ref. | Ref. | ||
3 | 639 | 2.47 (2.01–3.05) | < 0.001 | 1.31 (1.02–1.66) | 0.031 |
FIGO stagea | |||||
IA | 2720 | Ref. | Ref. | ||
IB | 942 | 2.22 (1.77–2.79) | < 0.001 | 1.34 (1.05–1.71) | 0.019 |
II | 295 | 3.36 (1.70–3.28) | < 0.001 | 1.55 (1.10–2.18) | 0.012 |
III | 303 | 5.18 (3.99–6.72) | < 0.001 | 2.60 (1.92–3.53) | < 0.001 |
Ploidy | |||||
Diploid | 3395 | Ref. | Ref. | ||
Non-diploid | 865 | 2.01 (1.64–2.45) | < 0.001 | 1.43 (1.15–1.78) | 0.001 |
LVSIa | |||||
No | 3544 | Ref. | Ref. | ||
Yes | 716 | 3.64 (3.00–4.42) | < 0.001 | 2.08 (1.66–2.61) | < 0.001 |
Age group (years) | |||||
0–59 | 886 | Ref. | Ref. | ||
60–69 | 1374 | 1.94 (1.26–3.00) | 0.003 | 1.94 (1.26–3.00) | 0.003 |
70–79 | 1405 | 4.10 (2.73–6.17) | < 0.001 | 3.82 (2.54–5.76) | < 0.001 |
80- | 595 | 10.8 (7.18–16.2) | < 0.001 | 9.6 (6.39–14.5) | < 0.001 |