Table 2 Endometrial cancer, FIGO stage I-III. Uni- and multivariable Cox proportional hazard regression analyzing overall survival including type of surgery, morphology, FIGO stage, ploidy, lymphovascular space invasion and age
Variables | No. of patients | Univariable Cox regression | Multivariable Cox regression | ||
|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | ||
Surgical approach | |||||
MIS | 2527 | Ref. | Ref. | ||
Open surgery | 2286 | 1.39 (1.18–1.63) | < 0.001 | 1.12 (0.95–1.32) | 0.19 |
Endometrioid | |||||
Yes | 4378 | Ref. | Ref. | ||
No | 435 | 3.91 (3.24–4.71) | < 0.001 | 1.75 (1.42–2.18) | < 0.001 |
FIGO stagea | |||||
IA | 2978 | Ref. | Ref. | ||
IB | 1019 | 2.09 (1.69–2.58) | < 0.001 | 1.32 (1.06–1.65) | 0.013 |
II | 359 | 3.07 (2.36–3.99) | < 0.001 | 1.81 (1.38–2.38) | < 0.001 |
III | 457 | 6.25 (5.10–7.67) | < 0.001 | 2.74 (2.16–3.49) | < 0.001 |
Ploidy | |||||
Diploid | 3534 | Ref. | Ref | ||
Non-diploid | 1279 | 2.75 (2.34–3.23) | < 0.001 | 1.59 (1.33–1.91) | < 0.001 |
LVSI | |||||
No | 3896 | Ref. | Ref. | ||
Yes | 917 | 4.24 (3.61–4.98) | < 0.001 | 2.25 (1.86–2.72) | < 0.001 |
Age group (years) | |||||
0–59 | 943 | Ref. | Ref. | ||
60–69 | 1535 | 2.11 (1.44–3.10) | < 0.001 | 1.88 (1.28–2.76) | 0.001 |
70–79 | 1624 | 4.40 (3.08–6.31) | < 0.001 | 3.66 (2.55–5.26) | < 0.001 |
80- | 711 | 10.7 (7.44–15.3) | < 0.001 | 8.65 (6.00–12.5) | < 0.001 |