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Table 2 Univariate analysis of clinical features affecting the prognosis of pancreatic cancer patients

From: Analysis of radiotherapy impact on survival in resected stage I/II pancreatic cancer patients: a population-based study

Clinical parameters

Stage I

Stage II

HR

95%CI

P

HR

95%CI

P

Age

  < 60

Ref

Ref

  ≥ 60

2.063

1.772–2.401

<0.001

1.263

1.204–1.324

<0.001

Year of diagnosis

 2004–2009

Ref

Ref

 2010–2015

0.897

0.785–1.024

0.109

0.866

0.830–0.902

<0.001

Sex

 Female

Ref

Ref

 Male

1.279

1.131–1.446

<0.001

1.042

1.000–1.085

0.049

Race

 Black

Ref

Ref

 White

1.077

0.880–1.319

0.470

0.959

0.895–1.028

0.242

 Other

0.760

0.567–1.020

0.067

0.911

0.823–1.008

0.072

Primary tumor Site

 Head

Ref

Ref

 Body

0.831

0.690–1.002

0.052

0.975

0.894–1.063

0.568

 tail

0.606

0.512–0.718

<0.001

0.909

0.848–0.974

0.007

 Pancreatic duct

0.856

0.536–1.368

0.517

0.876

0.725–1.058

0.169

 Overlapping

0.773

0.583–1.025

0.074

1.072

0.968–1.188

0.179

Pathological grade

 I

Ref

Ref

 II

1.811

1.499–2.187

<0.001

1.440

1.331–1.559

<0.001

 III

2.570

2.085–3.168

<0.001

1.902

1.754–2.061

<0.001

 IV

1.746

1.056–2.889

0.030

1.684

1.394–2.033

<0.001

 Unknown

1.039

0.829–1.303

0.739

1.147

1.031–1.276

0.012

T

 1

Ref

Ref

 2

1.371

1.201–1.564

<0.001

1.315

1.113–1.554

0.001

 3

1.295

1.113–1.506

0.001

N

 0

Ref

 1

1.446

1.380–1.516

<0.001

Chemotherapy

 No

Ref

Ref

 Yes

1.056

0.933–1.194

0.389

0.637

0.610–0.666

<0.001

Surgical procedures

 Local excision of tumor

Ref

Ref

 Pancreatectomy

0.900

0.428–1.894

0.782

0.752

0.551–1.026

0.072

 Extended

0.962

0.447–2.071

0.922

0.820

0.598–1.123

0.215

 Unknown

1.212

0.529–2.775

0.650

0.791

0.550–1.135

0.203

Radiotherapy

 No

 

Ref

 

Ref

 neoadjuvant RT

1.468

1.099–1.960

0.009

0.690

0.617–0.770

<0.001

 adjuvant RT

1.193

1.028–1.384

0.020

0.790

0.756–0.825

<0.001

  1. Abbreviations: RT Radiotherapy. Note: Pathological grade I, Well differentiated; II, Moderately differentiated; III, Poorly differentiated; IV, Undifferentiated; anaplastic. Pancreatectomy: partial pancreatectomy, local or partial pancreatectomy and duodenectomy with/without distal/partial gastrectomy, total pancreatectomy; Extended: total pancreatectomy and subtotal gastrectomy or duodenectomy, extended pancreatoduodenectomy