Fig. 6
From: Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer
TAPP accumulation in the skin over the tumour (SOT) and distant skin after topical application of TAPP on the SOT of LM3 bearing mice. TAPP was applied topically on SOT (100 μg TAPP in saline containing 10% DMSO). Animals were kept in the dark. At different times after application, TAPP fluorescence was monitored. Determinations were made on SOT and over a distant skin area. The average of three mice per treatment in 2 independent experiments is shown (a). Fluorescence and hematoxylin and eosin-stained images of SOT after 24 h of TAPP application. Magnification 10X objective (b)