Table 7 Univariate and multivariate analyses for RFS in patients with potential follow-up of more than 3 years (n = 826)

Age (> 50y vs ≤ 50y)

0.873

0.653–1.166

0.356

–

–

–

Menopausal status (pre/peri vs post)

1.044

0.757–1.440

0.793

–

–

–

Histological subtype (non-IDC vs IDC)

1.608

0.837–3.092

0.154

–

–

0.086

Tumour size (> 5 cm vs ≤ 5 cm)

1.407

1.022–1.939

0.036

1.433

1.046–1.965

0.025

Lymph node involvement (yes vs no)

1.763

1.281–2.427

0.001

1.727

1.258–2.372

0.001

 HR* (+) HER2 (−)

1

Ref.

Ref.

1

Ref.

Ref.

 HR* (+) HER2 (+)

1.350

0.890–2.046

0.158

1.409

0.929–2.136

0.107

 HR* (−) HER2 (+)

1.935

1.338–2.800

< 0.001

2.201

1.517–3.192

< 0.001

 HR* (−) HER2 (−)

2.391

1.626–3.516

<  0.001

2.746

1.861–4.051

< 0.001

Ki67 index (≤ 14% vs > 14%)

1.325

0.936–1.874

0.112

–

–

0.163

Fib status (high vs low)

1.095

0.787–1.523

0.589

–

–

0.584

pCR (no vs yes)

1.945

1.090–3.471

0.024

1.903

1.072–3.380

0.028