Differential gene expression identifies a transcriptional regulatory network involving ER-alpha and PITX1 in invasive epithelial ovarian cancer

Table 3 Proof of concept, ERα binding in the promoter regions of 28 differentially expressed genes (DEGs)

DEG comparison	Proportion of DEGs with ERα binding	DEGs with ERα binding^a
SBT vs HGSOC	4/11	HES2, RPL12, RPS15, SLC7A2
Stage II vs stage III HGSOC	9/17	ANK1, CA12, CHST15, ECE1, NQO1, PDGFC, PPP1R14C, SERPINE2, TSPAN1

Abbreviations: HGSOC High-grade serous ovarian cancer, SBT Serous borderline tumor
^a ERα binding determined using ChIP-seq data obtained from the UniBind repository from a breast cancer cell line (MCF7) and an endometrial cancer cell line (Ishikawa cells)

ISSN: 1471-2407