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Fig. 6 | BMC Cancer

Fig. 6

From: Differential gene expression identifies a transcriptional regulatory network involving ER-alpha and PITX1 in invasive epithelial ovarian cancer

Fig. 6

Experimental ChIP-seq data from the ovarian cancer cell line PEO4 illustrates transcription factors PITX1 and ERα co-occupying the promoter and gene bodies of three genes differentially expressed between epithelial ovarian cancer subtypes and stages. SLC7A2 and AFF2 were differentially expressed between serous borderline tumors (SBTs) and high-grade serous ovarian cancers (HGSOCs); TSPAN1 was differentially expressed between stage II and stage III HGSOCs. Binding data are displayed on tracks from the UCSC Human Genome Browser. Two experimental replicates were performed for each transcription factor, along with an input control. Blue asterisks indicate PITX1 binding and green asterisks ERα binding, where peaks displayed statistical significance above background for the relevant transcription factor. The vertical viewing axis was assigned the value of the highest peak and kept consistent for all panels at each locus

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