Table 4 Univariate and multivariate analyses using Cox proportional-hazards model for all patients based on overall survival

Age (>  70 vs. ≤ 70)

2.203

1.497–3.270

< 0.001

2.562

1.698–3.852

< 0.001

Sex (female vs. male)

1.172

0.771–1.793

0.460

0.404

T stage (T4 vs. T2/3)

2.772

1.850–4.144

< 0.001

1.560

0.940–2.581

0.085

N stage (N1–3 vs. N0)

3.724

2.292–6.041

< 0.001

3.007

1.663–5.461

< 0.001

Lauren’s classification (non-intestinal vs. intestinal)

1.334

0.898–1.962

0.154

0.675

Lymphatic invasion (yes vs. no)

3.141

1.921–5.143

< 0.001

1.481

0.790–2.789

0.219

Vascular invasion (yes vs. no)

1.713

1.054–2.761

0.030

1.209

0.734–2.021

0.455

R0 resection (no vs. yes)

2.662

1.552–4.580

< 0.001

0.631

0.181–2.171

0.461

High Noggin, invasive front (yes vs. no)

0.653

0.444–0.958

0.030

0.583

0.351–0.969

0.036

High Noggin, center lesion (yes vs. no)

0.867

0.591–1.283

0.481

High RBPMS2, invasive front (yes vs. no)

0.983

0.655–1.449

0.925

High RBPMS2, center lesion (yes vs. no)

1.162

0.792–1.710

0.446

EBV positivity (yes vs. no)

0.188

0.046–0.768

0.020

0.240

0.058–0.992

0.049

Peritoneal seeding (positive vs. negative)

3.102

1.549–4.584

< 0.001

2.065

0.588–7.231

0.256