Fig. 1

Representative immunohistochemical staining for Noggin and RBMPS2 expression in the paired cases of invasive front and tumor center of gastric cancer. High Noggin expression in tumor center [(a Original magnification ×40; scale bar, 500 μm) and (b Original magnification ×200; scale bar; 100 μm)] and deep invasive front [(c Original magnification × 40; scale bar, 500 μm)] and [(d Original magnification × 200; scale bar, 100 μm)] were detected; and high RBPMS2 expression in tumor center [(e Original magnification × 40; scale bar; 500 μm) and (f Original magnification × 200; scale bar; 100 μm)]; and low RBPMS2 expression in deep invasive front [(g Original magnification × 40; scale bar; 500 μm) and (h Original magnification × 200; scale bar; 100 μm)] were demonstrated. RBMPS2, RNA-binding protein for multiple splicing 2