Features | Univariate | Multivariate | ||
---|---|---|---|---|
HR (95%CI) | P value | HR (95%CI) | P value | |
Sex | ||||
Female | 1 | – | – | |
Male | 1.834 (0.589–5.712) | 0.295 | – | – |
Age | ||||
< 60 years old | 1 | 1 | ||
≥ 60 years old | 1.570 (1.256–1.962) | < 0.001 | 1.596 (1.257–2.025) | < 0.001 |
Race | ||||
White | 1 | 1 | ||
Black | 1.718 (1.325–2.226) | < 0.001 | 1.201 (0.918–1.572) | 0.181 |
Other | 0.462 (0.302–0.706) | < 0.001 | 0.433 (0.281–0.666) | < 0.001 |
Marital status | ||||
Married | 1 | 1 | ||
Singled | 2.448 (1.964–3.052) | < 0.001 | 1.679 (1.333–2.114) | < 0.001 |
Location | ||||
Central portion of breast | 1 | – | – | |
Upper-inner quadrant | 1.109 (0.691–1.781) | 0.667 | – | – |
Lower-inner quadrant | 0.677 (0.389–1.178) | 0.168 | – | – |
Upper-outer quadrant | 0.914 (0.615–1.358) | 0.656 | – | – |
Lower-outer quadrant | 0.754 (0.436–1.304) | 0.313 | – | – |
Unspecific | 3.152 (2.108–4.714) | < 0.001 | – | – |
Grade | ||||
I | 1 | – | – | |
II | 1.310 (1.031–1.665) | 0.027 | – | – |
III | 2.825 (1.931–4.133) | < 0.001 | – | – |
IV | 2.564 (0.635–10.345) | 0.186 | – | – |
SEER stage | ||||
Local | 1 | – | – | |
Regional | 4.427 (3.453–5.676) | < 0.001 | – | – |
Distant | 48.018 (37.616–61.296) | < 0.001 | – | – |
T-stage | ||||
T1 | 1 | 1 | ||
T2 | 2.680 (2.070–3.469) | < 0.001 | 1.971 (1.499–2.592) | < 0.001 |
T3 | 7.896 (5.726–10.889) | < 0.001 | 3.321 (2.279–4.838) | < 0.001 |
T4 | 30.059 (22.181–40.735) | < 0.001 | 4.382 (2.835–6.773) | < 0.001 |
N-stage | ||||
N0 | 1 | 1 | ||
N1 | 3.790 (2.881–4.985) | < 0.001 | 1.642 (1.194–2.256) | 0.002 |
N2 | 6.135 (3.789–9.932) | < 0.001 | 2.227 (1.316–3.769) | 0.003 |
N3 | 21.156 (14.901–30.036) | < 0.001 | 1.678 (1.052–2.674) | 0.030 |
M-stage | ||||
M0 | 1 | 1 | ||
M1 | 36.539 (28.835–46.302) | < 0.001 | 6.674 (4.771–9.336) | < 0.001 |
TNM stage | ||||
I | 1 | – | – | |
II | 2.967 (2.246–3.920) | < 0.001 | – | – |
III | 10.877 (7.662–15.440) | < 0.001 | – | – |
IV | 75.573 (56.325–101.399) | < 0.001 | – | – |
ER | ||||
Negative | 1 | 1 | ||
Positive | 0.372 (0.234–0.591) | < 0.001 | 0.559 (0.328–0.953) | 0.033 |
PR | ||||
Negative | 1 | 1 | ||
Positive | 0.498 (0.385–0.645) | < 0.001 | 0.730 (0.545–0.97) | 0.034 |
HER2 | ||||
Negative | 1 | – | – | |
Positive | 0.833 (0.339–2.046) | 0.691 | – | – |
Surgery | ||||
No | 1 | 1 | ||
Yes | ||||
Partial mastectomy | 0.047 (0.037–0.061) | < 0.001 | 0.334 (0.229–0.488) | < 0.001 |
Total mastectomya | 0.095 (0.070–0.129) | < 0.001 | 0.435 (0.299–0.631) | < 0.001 |
Radical mastectomyb | 0.148 (0.113–0.195) | < 0.001 | 0.470 (0.333–0.665) | < 0.001 |
Radiotherapy | ||||
No | 1 | 1 | ||
Yes | 0.316 (0.252–0.397) | < 0.001 | 0.668 (0.508–0.880) | 0.004 |