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Table 2 Univariate and multivariate analysis of CSS in MBC patients

From: The clinical features and prognosis of patients with mucinous breast carcinoma compared with those with infiltrating ductal carcinoma: a population-based study

Features

Univariate

 

Multivariate

 
 

HR (95%CI)

P value

HR (95%CI)

P value

Sex

 Female

1

 

 Male

1.834 (0.589–5.712)

0.295

Age

 < 60 years old

1

 

1

 

 ≥ 60 years old

1.570 (1.256–1.962)

< 0.001

1.596 (1.257–2.025)

< 0.001

Race

 White

1

 

1

 

 Black

1.718 (1.325–2.226)

< 0.001

1.201 (0.918–1.572)

0.181

 Other

0.462 (0.302–0.706)

< 0.001

0.433 (0.281–0.666)

< 0.001

Marital status

 Married

1

 

1

 

 Singled

2.448 (1.964–3.052)

< 0.001

1.679 (1.333–2.114)

< 0.001

Location

 Central portion of breast

1

 

 Upper-inner quadrant

1.109 (0.691–1.781)

0.667

 Lower-inner quadrant

0.677 (0.389–1.178)

0.168

 Upper-outer quadrant

0.914 (0.615–1.358)

0.656

 Lower-outer quadrant

0.754 (0.436–1.304)

0.313

 Unspecific

3.152 (2.108–4.714)

< 0.001

Grade

 I

1

 

 II

1.310 (1.031–1.665)

0.027

 III

2.825 (1.931–4.133)

< 0.001

 IV

2.564 (0.635–10.345)

0.186

SEER stage

 Local

1

 

 Regional

4.427 (3.453–5.676)

< 0.001

 Distant

48.018 (37.616–61.296)

< 0.001

T-stage

 T1

1

 

1

 

 T2

2.680 (2.070–3.469)

< 0.001

1.971 (1.499–2.592)

< 0.001

 T3

7.896 (5.726–10.889)

< 0.001

3.321 (2.279–4.838)

< 0.001

 T4

30.059 (22.181–40.735)

< 0.001

4.382 (2.835–6.773)

< 0.001

N-stage

 N0

1

 

1

 

 N1

3.790 (2.881–4.985)

< 0.001

1.642 (1.194–2.256)

0.002

 N2

6.135 (3.789–9.932)

< 0.001

2.227 (1.316–3.769)

0.003

 N3

21.156 (14.901–30.036)

< 0.001

1.678 (1.052–2.674)

0.030

M-stage

 M0

1

 

1

 

 M1

36.539 (28.835–46.302)

< 0.001

6.674 (4.771–9.336)

< 0.001

TNM stage

 I

1

 

 II

2.967 (2.246–3.920)

< 0.001

 III

10.877 (7.662–15.440)

< 0.001

 IV

75.573 (56.325–101.399)

< 0.001

ER

 Negative

1

 

1

 

 Positive

0.372 (0.234–0.591)

< 0.001

0.559 (0.328–0.953)

0.033

PR

 Negative

1

 

1

 

 Positive

0.498 (0.385–0.645)

< 0.001

0.730 (0.545–0.97)

0.034

HER2

 Negative

1

 

 Positive

0.833 (0.339–2.046)

0.691

Surgery

 No

1

 

1

 

 Yes

    

  Partial mastectomy

0.047 (0.037–0.061)

< 0.001

0.334 (0.229–0.488)

< 0.001

  Total mastectomya

0.095 (0.070–0.129)

< 0.001

0.435 (0.299–0.631)

< 0.001

  Radical mastectomyb

0.148 (0.113–0.195)

< 0.001

0.470 (0.333–0.665)

< 0.001

Radiotherapy

 No

1

 

1

 

 Yes

0.316 (0.252–0.397)

< 0.001

0.668 (0.508–0.880)

0.004

  1. aA simple mastectomy removes all breast tissue, the nipple, and areolar complex. An axillary dissection is not done
  2. bRadical mastectomy includes modified radical mastectomy, radical mastectomy NOS and extended radical mastectomy