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Fig. 3 | BMC Cancer

Fig. 3

From: The effects of secondary iron overload and iron chelation on a radiation-induced acute myeloid leukemia mouse model

Fig. 3

Leukemogenesis, changes of signaling networks, and the influence of iron and ICT. Progressive enhancement (light to dark red fill) and suppression (light to dark green fill) of various signaling networks were listed with their corresponding leukemic stages (normal to pre-AML to AML). Signaling networks were grouped into survival/proliferation (S/P, red outline), apoptosis/tumor suppression (A/T, green outline) and mutagenesis (M, blue outline) based on the combined gene expressions and biomarkers analysis. AOD – antioxidant defenses, DDR – DNA damage response

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BMC Cancer

ISSN: 1471-2407

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