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Table 4 All-cause hospitalization

From: Prophylactic pegfilgrastim to prevent febrile neutropenia among patients receiving biweekly (Q2W) chemotherapy regimens: a systematic review of efficacy, effectiveness and safety

Study

All-cause hospitalization

Bozzoli [20]

 

Total (n = 51)

Pegfilgrastim (n = 27)

Filgrastim (n = 24)

p value

Unplanned hospitalizations per patient, n (%)

8/51 (16)

5/27 (19)

3/24 (13)

0.7

Unplanned hospitalizations per cycle, n (%)

12/201 (6)

7/105 (7)

5/96 (5)

0.8

Donkor [21]

 

Pegfilgrastim < 14 days group (n = 126)

Pegfilgrastim > 14 days group (n = 25)

Filgrastim group (n = 90)

No CSF group (n = 295)

Number of cycles with hospitalizations for FN,a n (%)

0 (0)

0 (0)

0 (0)

1 (0.3)

Hecht [23]

 

Placebo (n = 118)

Pegfilgrastim (n = 123)

p value

Hospitalized due to a neutropenic event, %

8

6

0.55

Hendler [24]a,b

 

Total

Group A

Group B

Group C

Group D

Total treated, n (%)

231 (100)

84 (36.3)

26 (11.3)

64 (27.7)

57 (24.7)

Hospitalized due to FN, n (%)

13 (5.6)

3 (3.6)

3 (11.5)

1 (1.5)

6 (10.5)

Lugtenburg [28]

 

R-CHOP-14

R-CHOP-21

<  65 years (n = 241)

≥ 65 years (n = 168)

<  65 years (n = 343)

≥ 65 years (n = 361)

Hospitalization per group, %

26

40

22

36

PP per intervention, %

54

58

17

32

Hospitalization of pegfilgrastim-treated patients, %

14

23

4

12

Ng [29]

 

CHOP-21 (n = 72)

CHOP-14 (n = 60)

p value

Hospitalizationb, %

23.6

11.7

p = 0.1

  1. aGroup A: G-CSF 300 μg consecutive administrations during days 3–10; group B: G-CSF 300 μg consecutive administrations during days 3–7; group C: G-CSF administrations every other day for days 5, 7, 9, and 11; and group D: one administration of pegfilgrastim 6 mg on day 2
  2. bEach chemotherapy cycle (not number of patients) was the unit of measurement
  3. CHOP cyclophosphamide, doxorubicin, vincristine, and prednisone, CSF colony-stimulating factor, FN febrile neutropenia, G-CSF granulocyte colony-stimulating factor, PP prophylactic pegfilgrastim, R-CHOP rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone