Table 4 Multivariate analysis of factors associated with overall survival in patients with Siewert type II/III AEG
Variable | Training cohort (n = 203) | Validation-1 cohort (n = 88) | Validation-2 cohort (n = 105) | |||
|---|---|---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
Blood transfusion (vs. No) | 1.260 (1.046–1.517) | 0.015 | NA |  | NA |  |
Organ invasion (vs. Absence) | NA |  | 2.124 (1.051–4.293) | 0.036 | NA |  |
Serosal infiltration (vs. S0) | NA |  | NA |  | 1.852 (1.287–2.667) | 0.001 |
Borrmann type (vs. I) | NA | Â | NA | Â | NA | Â |
pTNM stage (vs. I-II) | 1.438 (1.007–2.053) | 0.046 | NA |  | NA |  |
Grade of differentiation (vs. Well) | NA | Â | NA | Â | NA | Â |
PLNa | NA | Â | NA | Â | NA | Â |
LNRa | NA | Â | NA | Â | NA | Â |
LODDSa | 1.478 (1.322–1.651) | < 0.001 | 1.561 (1.237–1.970) | < 0.001 | 1.323 (1.079–1.623) | 0.007 |
PLT (vs. < 229) | NA |  | 0.400 (0.198–0.809) | 0.011 | NA |  |
ALB (vs. < 39.4) | NA |  | NA |  | NA |  |
CA-125 (vs. < 9.70) | NA |  | NA |  | NA |  |