Table 3 Univariate analysis of factors associated with disease-free survival in patients with Siewert type II/III AEG

Gender (vs. Male)

0.952 (0.618–1.466)

0.823

1.419 (0.718–2.803)

0.314

1.144 (0.574–2.278)

0.702

Age (vs. ≤40)

0.799 (0.643–0.993)

0.043

1.002 (0.642–1.563)

0.994

0.936 (0.659–1.330)

0.711

Family history of cancer (vs. No)

0.645 (0.363–1.146)

0.135

0.958 (0.604–1.519)

0.855

1.098 (0.694–1.738)

0.689

Blood transfusion (vs. No)

1.247 (1.046–1.486)

0.014

1.124 (0.772–1.637)

0.541

1.361 (1.033–1.793)

0.028

Siewert type (vs. II)

1.111 (0.780–1.581)

0.560

1.271 (0.661–2.443)

0.472

0.995 (0.571–1.735)

0.986

Organ invasion (vs. Absence)

2.470 (1.708–3.572)

< 0.001

1.955 (1.006–3.800)

0.048

2.145 (1.208–3.812)

0.009

Serosal infiltration (vs. S0)

1.474 (1.228–1.770)

< 0.001

1.434 (1.040–1.979)

0.028

1.947 (1.404–2.699)

< 0.001

Borrmann type (vs. I)

1.573 (1.160–2.133)

0.004

1.640 (1.007–2.671)

0.047

1.990 (1.235–3.207)

0.005

PRM (vs. < 3 cm)

0.846 (0.595–1.204)

0.353

1.221 (0.515–2.894)

0.650

1.198 (0.623–2.302)

0.589

DRM (vs. < 12 cm)

0.761 (0.536–1.079)

0.126

0.598 (0.311–1.152)

0.124

1.075 (0.591–1.956)

0.812

pTNM stage (vs. I-II)

3.128 (1.934–5.058)

< 0.001

1.660 (0.800–3.445)

0.174

2.332 (1.199–4.537)

0.013

Grade of differentiation (vs. Well)

1.485 (1.036–2.127)

0.031

3.455 (1.468–8.133)

0.005

2.676 (1.260–5.685)

0.010

Complications (vs. 0-I)

1.220 (0.782–1.904)

0.381

3.504 (1.711–7.175)

0.001

1.165 (0.632–2.148)

0.624

PLN^a

1.052 (1.037–1.067)

< 0.001

1.060 (1.014–1.108)

0.011

1.059 (1.035–1.084)

< 0.001

LNR^a

11.958 (6.262–22.834)

< 0.001

31.083 (5.305–182.122)

< 0.001

16.295 (4.944–53.705)

< 0.001

LODDS^a

1.485 (1.343–1.641)

< 0.001

1.543 (1.222–1.948)

< 0.001

1.414 (1.176–1.700)

< 0.001

FOBT (vs. Negative)

0.965 (0.592–1.572)

0.887

1.444 (0.632–3.298)

0.383

1.904 (1.067–3.398)

0.029

WBC (vs. < 6.02)

1.180 (0.832–1.675)

0.353

0.653 (0.338–1.260)

0.204

0.961 (0.561–1.648)

0.886

Neut (vs. < 3.25)

1.113 (0.784–1.578)

0.550

0.682 (0.354–1.311)

0.251

1.164 (0.659–2.056)

0.600

Hb (vs. < 128)

0.811 (0.571–1.151)

0.241

1.348 (0.700–2.593)

0.372

1.216 (0.707–2.091)

0.480

HCT (vs. < 0.380)

0.810 (0.571–1.149)

0.238

1.527 (0.787–2.963)

0.211

0.945 (0.551–1.622)

0.838

PLT (vs. < 229)

1.512 (1.063–2.151)

0.022

0.524 (0.270–1.018)

0.056

0.995 (0.581–1.705)

0.986

Blood type (vs. A)

0.937 (0.812–1.082)

0.379

1.325 (0.999–1.755)

0.050

0.876 (0.714–1.074)

0.202

ALB (vs. < 39.4)

0.737 (0.518–1.047)

0.089

0.938 (0.479–1.834)

0.851

1.323 (0.766–2.286)

0.315

GLB (vs. < 25.9)

0.798 (0.562–1.134)

0.208

2.177 (1.049–4.517)

0.037

1.397 (0.797–2.450)

0.243

AFP (vs. < 3.41)

0.750 (0.528–1.065)

0.108

1.219 (0.617–2.407)

0.569

1.270 (0.729–2.214)

0.399

CEA (vs. < 2.94)

1.301 (0.916–1.849)

0.141

1.119 (0.580–2.161)

0.737

1.348 (0.785–2.317)

0.279

CA-125 (vs. < 9.70)

1.410 (0.991–2.008)

0.056

1.503 (0.775–2.917)

0.228

1.407 (0.802–2.468)

0.234

CA 19–9 (vs. < 9.39)

1.328 (0.935–1.887)

0.113

0.768 (0.384–1.536)

0.456

1.618 (0.943–2.776)

0.081