Table 2 Univariate analysis of factors associated with overall survival in patients with Siewert type II/III AEG

Gender (vs. Male)

0.926 (0.596–1.436)

0.730

1.623 (0.812–3.243)

0.170

1.359 (0.675–2.734)

0.390

Age (vs. ≤40)

0.819 (0.659–1.018)

0.073

0.981 (0.629–1.527)

0.931

1.079 (0.716–1.627)

0.717

Family history of cancer (vs. No)

0.658 (0.370–1.170)

0.154

0.775 (0.433–1.387)

0.391

1.172 (0.739–1.857)

0.500

Blood transfusion (vs. No)

1.300 (1.091–1.548)

0.003

1.194 (0.821–1.738)

0.353

1.471 (1.110–1.949)

0.007

Siewert type (vs. II)

1.010 (0.706–1.446)

0.956

1.262 (0.644–2.471)

0.498

1.116 (0.623–1.999)

0.711

Organ invasion (vs. Absence)

2.402 (1.653–3.492)

< 0.001

2.189 (1.110–4.315)

0.024

2.510 (1.387–4.543)

0.002

Serosal infiltration (vs. S0)

1.556 (1.292–1.875)

< 0.001

1.541 (1.104–2.150)

0.011

2.030 (1.432–2.876)

< 0.001

Borrmann type (vs. I)

1.670 (1.223–2.280)

0.001

1.716 (1.034–2.849)

0.037

1.887 (1.152–3.093)

0.012

PRM (vs. < 3 cm)

0.862 (0.601–1.237)

0.421

0.914 (0.387–2.157)

0.914

1.048 (0.517–2.126)

0.896

DRM (vs. < 12 cm)

0.805 (0.565–1.147)

0.229

0.479 (0.244–0.941)

0.033

0.901 (0.488–1.664)

0.739

pTNM stage (vs. I-II)

3.128 (1.913–5.112)

< 0.001

2.121 (0.959–4.690)

0.063

2.554 (1.233–5.290)

0.012

Grade of differentiation (vs. Well)

1.154 (1.074–2.248)

0.019

3.140 (1.331–7.409)

0.009

2.634 (1.178–5.889)

0.018

Complications (vs. 0-I)

1.245 (0.791–1.960)

0.343

3.083 (1.467–6.479)

0.003

1.442 (0.771–2.699)

0.252

PLN^a

1.059 (1.043–1.074)

< 0.001

1.067 (1.019–1.117)

0.005

1.061 (1.035–1.088)

< 0.001

LNR^a

15.192 (8.172–30.981)

< 0.001

29.957 (5.339–168.076)

< 0.001

20.054 (5.736–70.106)

< 0.001

LODDS^a

1.548 (1.395–1.719)

< 0.001

1.598 (1.261–2.026)

< 0.001

1.425 (1.170–1.736)

< 0.001

FOBT (vs. Negative)

0.883 (0.535–1.456)

0.626

1.553 (0.676–3.567)

0.300

2.359 (1.296–4.292)

0.005

WBC (vs. < 6.02)

1.251 (0.877–1.783)

0.216

0.577 (0.291–1.144)

0.115

0.829 (0.467–1.471)

0.521

Neut (vs. < 3.25)

1.166 (0.818–1.660)

0.396

0.624 (0.318–1.225)

0.171

1.072 (0.591–1.944)

0.819

Hb (vs. < 128)

0.780 (0.547–1.113)

0.171

1.121 (0.572–2.197)

0.738

1.087 (0.609–1.939)

0.778

HCT (vs. < 0.380)

0.797 (0.559–1.137)

0.210

1.298 (0.660–2.555)

0.450

0.795 (0.445–1.418)

0.436

PLT (vs. < 229)

1.492 (1.044–2.131)

0.028

0.531 (0.268–1.053)

0.070

0.887 (0.500–1.573)

0.681

Blood type (vs. A)

0.939 (0.813–1.085)

0.396

1.263 (0.952–1.675)

0.106

0.830 (0.669–1.030)

0.091

ALB (vs. < 39.4)

0.674 (0.472–0.964)

0.031

0.897 (0.449–1.793)

0.759

1.159 (0.643–2.089)

0.623

GLB (vs. < 25.9)

0.853 (0.598–1.216)

0.379

1.960 (0.937–4.101)

0.074

1.837 (0.983–3.434)

0.057

AFP (vs. < 3.41)

0.790 (0.554–1.126)

0.193

1.358 (0.680–2.712)

0.386

1.415 (0.790–2.535)

0.243

CEA (vs. < 2.94)

1.283 (0.899–1.930)

0.170

0.951 (0.480–1.884)

0.886

1.343 (0.755–2.387)

0.315

CA-125 (vs. < 9.70)

1.561 (1.090–2.236)

0.015

1.424 (0.719–2.820)

0.310

1.404 (0.774–2.548)

0.264

CA 19–9 (vs. < 9.39)

1.395 (0.977–1.991)

0.067

0.890 (0.441–1.800)

0.747

1.453 (0.820–2.576)

0.201